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Neonatal beta cells are considered developmentally immature and hence less glucose-responsive. To study the acquisition of mature glucose-responsiveness, we compared glucose-regulated redox state, insulin synthesis and secretion of beta cells purified from neonatal or 10-weeks old rats to their tran...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-12-12 | PXD001577 | Pride
Gaucher disease (GD) is characterized by the presence of glucosylceramide-laden macrophages (Gaucher cells) as the result of deficiency in the lysosomal hydrolase glucocerebrosidase (GBA). Non-neuronopathic type 1 GD is effectively treated by infusions with macrophage-targeted recombinant glucocereb...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD001598 | Pride
We used quantitative (phospho)proteomics to study how cells may escape the activity of RET kinase inhibitors.
ORGANISM(S): Homo sapiens (Human) 
2017-06-21 | PXD006006 | Pride
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