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TranscriptomicsMicroarray gene expression profiling of a fibrosarcoma GPNMB-induced cell line MCA-1-GPNMB at basal condition and in the form of spheroids
The expression of the soluble protein GPNMB (glycoprotein non-metastatic melanoma protein B) induces an aggressive behavior of tumor cells by promoting proliferation and distant spread. The main molecular feature is the over expression of interleukin Il-33. The gene profile of MCA-1-GPNMB and MCA-1-...
ORGANISM(S): Mus musculus 
2020-07-30 | E-MTAB-8082 | biostudies-arrayexpress
TranscriptomicsTrans. Profiling of Immortalized Melanocyte Cell Lines Identifies GPNMB as a Melanoblast-Expressed, MITF-Dependent Gene
Gene expression profiling of tissues derived from different genetic backgrounds can provide insight to potential phenotype-related changes in gene expression. We have compared wildtype C57BL/6 (melan-Ink4a) melanocyte cell gene expression to that of, “brown“ Tyrp1b/ b (melan-Ink4a-b) and “cho...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-10163 | biostudies-arrayexpress
ProteomicsMS assay of proteins after CO-IP with GPNMB antibody in hippocampus area
Three mice were excised at day 7 after pilocarpine treatment to induce abundant GPNMB expression (Figures 1 and 2). Hippocampal proteins were extracted and pulled down by anti-GPNMB immunoprecipitation for mass-spectrometer assay.
ORGANISM(S): Mus Musculus 
PXD066376 |
ProteomicsCOMPARATIVE PROTEOMICS ANALYSIS OF THE IRIDOCORNEAL REGION OF DBA/2J AND DBA/2J-Gpnmb+/SjJ MICE
In this study, we performed a comparative proteomics analysis of the iridocorneal region in DBA/2J and Gpnmb+ mice to gain deeper insight into the molecular mechanisms underlying IOP elevation following iris pigment dispersion/
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD064786 | Pride
Gpnmb Proteomics Glaucoma Ocular hypertension Outflow pathway Dba/2j Iridocorneal region 
ProteomicsElevated gpNMB in type 1 Gaucher disease patients
Gaucher disease (GD) is characterized by the presence of glucosylceramide-laden macrophages (Gaucher cells) as the result of deficiency in the lysosomal hydrolase glucocerebrosidase (GBA). Non-neuronopathic type 1 GD is effectively treated by infusions with macrophage-targeted recombinant glucocereb...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD001598 | Pride
Gpnmb Lcmse Gaucher disease Proteomics Biomarker 
GenomicsHepatic GPNMB aggravates NASH through binding to RYK [RNA-Seq]
Hepatic GPNMB aggravates NASH through binding to RYK [RNA-Seq]
PRJNA1084732 | ENA
GenomicsGpnmb is required for immune and fibrotic responses during zebrafish heart regeneration
Gpnmb is required for immune and fibrotic responses during zebrafish heart regeneration
PRJNA1125393 | ENA
GenomicsRole of GPNMB in Foam Cells Formation and Atherosclerosis Progression
Role of GPNMB in Foam Cells Formation and Atherosclerosis Progression
PRJNA1148641 | ENA
GenomicsGPNMB confers risk for Parkinson’s disease through interaction with alpha-synuclein
GPNMB confers risk for Parkinson’s disease through interaction with alpha-synuclein
PRJNA850079 | ENA
GenomicsGpnmb is required for immune and fibrotic responses during zebrafish heart regeneration
Gpnmb is required for immune and fibrotic responses during zebrafish heart regeneration
PRJNA1125013 | ENA
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