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ProteomicsQuantitation of plasma protein concentrations by mass spectrometry without the use of isotopic standards. C4PR_LIV
We applied a non targeted mass spectrometric assay (LCMSE), to quantify 55 abundant plasma proteins in specimens from 31 healthy volunteers. Quantitation was done by HI3 peptide measurement using a single internal standard to estimate protein concentrations. Results for 7 apolipoproteins were compar...
ORGANISM(S): Homo sapiens (Human) 
2015-10-20 | PXD000347 | Pride
Lcmse Quantitation Mass spectrometry Plasma proteins Proteomics Immunoassay 
ProteomicsMass spectrometry based quantitative proteome analyses for the import mutants ppi2 and tic56-1 as well as for spectinomycin treated Arabidopsis thalian plants
We acquired quantitative proteomics data from eight week old ppi2 and tic56-1 mutants as well as from wild type treated with 60 µg/ml spectinomycin and related them to their respective wildtype reference. Protein identification and quantification was performed by data-independent MSE acquisition on ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-12-14 | PXD004125 | Pride
Hdmse Tic56-1 Plastid Spectinomycin Plastidic translation Quantitative mass spectrometry Shotgun proteomics Toc-tic-import machinery Hi3 quantification Ppi2 
UnknownAccuracy and Reproducibility in Quantification of Plasma Protein Concentrations by Mass Spectrometry without the Use of Isotopic Standards.
Not available
S-EPMC4608811 | biostudies-literature
ProteomicsDynamics of the physiology, metabolome and proteins during the circadian cycle of Synechocystis sp. PCC 6803 under culturing conditions relevant for mass culturing
Here, we present the results of a study of the model cyanobacterium Synechocystis sp. PCC 6803, cultured in a lab-scale photobioreactor simulating physiological conditions present during large-scale culturing. The culture is flushed with N2 and CO2 without additional O2. This leads to an anoxic envi...
ORGANISM(S): Synechocystis sp. PCC 6803 
2016-09-27 | PXD001619 | Pride
Lcmse Synechocystis sp. pcc 6803 Proteomics 
ProteomicsEvolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome
Microsporidia are eukaryotic parasites that infect essentially all animal species, including many of agricultural importance, and are significant opportunistic parasites of humans. They are characterized by having a specialized infection apparatus, an obligate intracellular lifestyle, rudimentary mi...
ORGANISM(S): Vairimorpha necatrix 
2019-07-02 | PXD013432 | Pride
Cryo-em Vairimorpha necatrix Mass spectrometry Ribosome Microsporidia 
ProteomicsElevated gpNMB in type 1 Gaucher disease patients
Gaucher disease (GD) is characterized by the presence of glucosylceramide-laden macrophages (Gaucher cells) as the result of deficiency in the lysosomal hydrolase glucocerebrosidase (GBA). Non-neuronopathic type 1 GD is effectively treated by infusions with macrophage-targeted recombinant glucocereb...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD001598 | Pride
Gpnmb Lcmse Gaucher disease Proteomics Biomarker 
ProteomicsFunctional characteristics of neonatal rat beta cells With distinct markers
Neonatal beta cells are considered developmentally immature and hence less glucose-responsive. To study the acquisition of mature glucose-responsiveness, we compared glucose-regulated redox state, insulin synthesis and secretion of beta cells purified from neonatal or 10-weeks old rats to their tran...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-12-12 | PXD001577 | Pride
Lcmse Rat Diabetes Label free quantitation Pancreas 
ProteomicsQuantitative proteomics of human pancreatic beta cells
Outline: using label-free alternate-scanning LC-MS/MS, we compared the proteomic architecture of core functional pathways in pancreatic beta cells of human origin. Results: we quantified the relative molar abundance of 707 proteins mainly composed of functional pathways of metabolism, protein synthe...
ORGANISM(S): Homo sapiens (Human) 
2015-08-07 | PXD001539 | Pride
Human Lcmse Diabetes Biomarker Proteomics Islet beta cell Pancreas 
ProteomicsControl of protein accumulation by the LON2 peroxisomal protease and autophagy
Peroxisomes are membrane-bound eukaryotic organelles that house essential metabolic pathways. Many of these pathways generate damaging reactive oxygen species (ROS) that also function as signaling molecules. In Arabidopsis thaliana, damaged or obsolete peroxisomal proteins can be degraded by the LON...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-05-06 | PXD022921 | Pride
Protease Peroxisomes Pexophagy Chaperone 
ProteomicsMaize seed proteome of autophagy deficient plants throughout development
Autophagy or ‘self-eating’ is a conserved and essential route for recycling intracellular constituents in eukaryotes. For plants, autophagy supports robust crop performance by regulating traits such as nitrogen-use efficiency, carbon allocation, reproduction, grain fill, and protection against vari...
ORGANISM(S): Zea mays (Maize) 
2023-03-10 | PXD022863 | Pride
Autophagy Maize Seed development Atg12 
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