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GenomicsPexophagy-driven redox imbalance promotes virus-induced ferroptosis
Pexophagy-driven redox imbalance promotes virus-induced ferroptosis
PRJNA1255113 | ENA
TranscriptomicsPexophagy-driven redox imbalance promotes virus-induced ferroptosis
Peroxisomes are critical organelles that maintain cellular redox homeostasis. Many viruses induce oxidative stress and degrade peroxisomes, but the mechanisms and consequences remain unclear. In this study, we systematically investigate how virus-induced pexophagy regulates peroxisome homeostasis. U...
ORGANISM(S): Homo sapiens 
2025-04-29 | GSE295522 | GEO
ProteomicsIncreasing Pexophagy as an Unconventional Mode to Kill Cancer Cells
The autophagy-mediated degradation of peroxisomes, pexophagy, serves as a rheostat for peroxisome homeostasis. However, disturbing this process has yet to be investigated in the context of therapy treatment and resistance in cancer. In Vorinostat (Vor)-resistant lymphoma (B8) cells, an autophagosom...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD013926 | Pride
Metabolism Autophagy Cancer Exportomer Peroxisome Pexophagy 
ProteomicsPEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy
Peroxisome degradation, known as pexophagy, is essential for eliminating surplus and dysfunctional peroxisomes, with dysregulation linked to various diseases. Previous research revealed that ectopic expression of optineurin (OPTN), a versatile autophagy adaptor involved in multiple autophagic pathwa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-23 | PXD053489 | Pride
Pex14 Peroxisomes Pexophagy Ubiquitin Optineurin 
UnknownPeroxisome and pexophagy in neurological diseases.
Not available
S-EPMC11670711 | biostudies-literature
UnknownSegregation of pathways leading to pexophagy.
Not available
S-EPMC9944197 | biostudies-literature
UnknownBNIP3L/NIX regulates both mitophagy and pexophagy.
Not available
S-EPMC9753467 | biostudies-literature
UnknownLoss of HSPA9 induces peroxisomal degradation by increasing pexophagy.
Not available
S-EPMC7595578 | biostudies-literature
UnknownUpregulated pexophagy limits the capacity of selective autophagy.
Not available
S-EPMC10776696 | biostudies-literature
UnknownThe membrane peroxin PEX3 induces peroxisome-ubiquitination-linked pexophagy.
Not available
S-EPMC4206534 | biostudies-literature
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