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MetabolomicsInfection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication
Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread...
2018-10-22 | MTBLS652 | MetaboLights
MetabolomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to st...

2025-04-25 | MTBLS12329 | MetaboLights
MetabolomicsA multi-omics approach to study peroxisome proliferator-activated receptor mediated regulation of lipid metabolism in Atlantic cod (Gadus morhua)
Lipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, a group of nuclear receptor transcription factors named peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in these processes. We have rec...
2022-02-28 | MTBLS2131 | MetaboLights
MetabolomicsLipidomics study of the cells defective in peroxisome division
Not available
ORGANISM(S): Homo sapiens 
ST002346 | MetabolomicsWorkbench
TranscriptomicsA Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders
Human peroxisome biogenesis disorders are lethal genetic disease in which abnormal peroxisome assembly compromises overall peroxisome and cellular function. Peroxisomes are ubiquitous membrane-bound organelles involved in several important biochemical processes, notably lipid metabolism and the use ...
ORGANISM(S): Drosophila melanogaster 
2011-07-02 | E-GEOD-30362 | biostudies-arrayexpress
ProteomicsPex3 promotes formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites
Peroxisomes are ubiquitous organelles that mediate central metabolic functions, such as fatty acid β-oxidation, as well as diverse tissue- and organism-specific processes. Membrane contact sites, regions of close apposition with other organelles for direct communication, are central to several aspec...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-22 | PXD063514 | Pride
Yeast turboid pex3 contact sites peroxisomes lipid droplets 
ProteomicsPeroxisome-derived hydrogen peroxide can modulate the sulfenylation profiles of key redox signaling proteins in Flp-In T-REx 293 cells
Ever since the first characterization of peroxisomes, a central theme has been their involvement in cellular hydrogen peroxide (H2O2) metabolism. While the reputation of H2O2 drastically changed from an exclusively toxic molecule to a signaling messenger, the regulatory role of peroxisomes in these ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-10 | PXD030782 | Pride
Peroxisome  hydrogen peroxide  cysteine thiol group  yap1c-based sulfenome mining  peroxiredoxin  mitochondrion 
ProteomicsIsolated peroxisome-division machinery
LC-MS/MS analysis was performed to determine enriched protein in the fraction of isolated peroxisome-division machinery. Fraction was acquired from uni-cellular red algae Cyanidioschyzon merolae during mitotic phase which contains dividing peroxisome.
ORGANISM(S): Cyanidioschyzon Merolae Strain 10d 
2018-09-21 | PXD010716 | JPOST Repository
ProteomicsHuman cytomegalovirus alters the peroxisome proteome
Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g., plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and sprea...
ORGANISM(S): Homo sapiens (Human) Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) 
2018-10-04 | PXD009321 | Pride
Human Hcmv Peroxisome Prm Virus Cytomegalovirus Fibroblast 
TranscriptomicsTranscription profiling of mouse skeletal muscle overexpressing PPARalpha
This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link betw...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5777 | biostudies-arrayexpress
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