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ProteomicsPEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy
Peroxisome degradation, known as pexophagy, is essential for eliminating surplus and dysfunctional peroxisomes, with dysregulation linked to various diseases. Previous research revealed that ectopic expression of optineurin (OPTN), a versatile autophagy adaptor involved in multiple autophagic pathwa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-23 | PXD053489 | Pride
Pex14 Peroxisomes Pexophagy Ubiquitin Optineurin 
UnknownMembrane Interactions of the Peroxisomal Proteins PEX5 and PEX14.
Not available
S-EPMC8086558 | biostudies-literature
ProteomicsAnaerobic peroxisomes in Entamoeba histolytica metabolize myo-inositol
E. histolytica is believed to be devoid of peroxisomes, like most anaerobic protists. In this work, we provided the first evidence that peroxisomes are present in E. histolytica, although the set of proteins (peroxins) responsible for peroxisome biogenesis was reduced to only seven members (Pex1, Pe...
ORGANISM(S): Entamoeba histolytica 
2021-10-29 | PXD026653 | Pride
Inositol dehydrogenase Peroxisomes Entamoeba histolytica Pts1 Pex 
UnknownStructural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
Not available
S-EPMC2666029 | biostudies-literature
UnknownIdentification of a novel PEX14 mutation in Zellweger syndrome.
Not available
S-EPMC3027610 | biostudies-literature
UnknownThe coiled-coil domain of glycosomal membrane-associated Leishmania donovani PEX14: cloning, overexpression, purification and preliminary crystallographic analysis.
Not available
S-EPMC7531246 | biostudies-literature
UnknownPex13 and Pex14, the key components of the peroxisomal docking complex, are required for peroxisome formation, host infection and pathogenicity-related morphogenesis in Magnaporthe oryzae.
Not available
S-EPMC6527019 | biostudies-literature
UnknownPeroxin Pex14/17 Is Required for Trap Formation, and Plays Pleiotropic Roles in Mycelial Development, Stress Response, and Secondary Metabolism in Arthrobotrys oligospora.
Not available
S-EPMC10117088 | biostudies-literature
UnknownPeroxisome Deficiency Dysregulates Fatty Acid Oxidization and Exacerbates Lipotoxicity in β Cells.
Not available
S-EPMC8405300 | biostudies-literature
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry – PEX14c
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD004972 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
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