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ProteomicsMass spectrometric ITEM-ONE analysis confirms and refines an assembled affimer binding site on the HER-2 targeting therapeutic antibody Pertuzumab
The Pertuzumab-binding affimer 00557_709097 was incubated either with peptides from tryptically digested Pertuzumab or with selected synthesized peptides. Affimer-peptide complexes were subjected to nano electrospray mass spectrometric ITEM analyses in order to identify the affimer’s epitope on Pert...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD043203 | Pride
Pertuzumab Item Affimer Offline nanoesi-ms 
ProteomicsAffimer reagents as tools to modulate GPVI-ligand interactions
We have isolated Affimers that bind to GPVI and characterized their effect on receptor function. An affimer that binds specifically to dimeric GPVI was identified as a novel tool to detect dimeric GPVI. The binding sites of the different Affimers were mapped using HDX-MS, revealing that they interac...
ORGANISM(S): Homo sapiens (Human) 
2024-10-01 | PXD046982 | Pride
Hdx-ms Gpvi 
UnknownAffimer proteins are versatile and renewable affinity reagents.
Not available
S-EPMC5487212 | biostudies-literature
UnknownGenerating and validating renewable affimer protein binding reagents targeting SH2 domains.
Not available
S-EPMC11569188 | biostudies-literature
UnknownDevelopment of an Affimer-antibody combined immunological diagnosis kit for glypican-3.
Not available
S-EPMC5575301 | biostudies-literature
UnknownExploiting the Affimer platform against influenza A virus.
Not available
S-EPMC11323568 | biostudies-literature
UnknownLabeling of a mutant estrogen receptor with an Affimer in a breast cancer cell line.
Not available
S-EPMC9617163 | biostudies-literature
UnknownUse of Affimer technology for inhibition of α2-antiplasmin and enhancement of fibrinolysis.
Not available
S-EPMC11742610 | biostudies-literature
UnknownPhage display identifies Affimer proteins that direct calcium carbonate polymorph formation.
Not available
S-EPMC11358866 | biostudies-literature
ProteomicsCharacterisation of TACC3 affimer interactions by HDX-MS
Here we characterise the interactions of affimers against TACC3 by HDX-MS.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052409 | Pride
Hdx Taac3 Affimer 
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