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ProteomicsAffinity capture enrichment versus Affinity depletion: A comparison of strategies for increasing coverage of low abundant human plasma proteins
present study, we evaluated four small molecule affinity-based probes based on agarose-immobilized benzamidine (ABA), O-Phospho-L-Tyrosine (pTYR), 8-Amino-hexyl-cAMP (cAMP), or 8-Amino-hexyl-ATP (ATP) for their ability to remove high-abundant proteins such as serum albumin from plasma samples thereb...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD020727 | Pride
Affinity enrichment Depletion Human plasma 
ProteomicsHuman Plasma Discovery Proteomics
This study addresses this gap by conducting a direct comparison of eight platforms, representing both affinity-based and diverse mass spectrometry approaches, and covering over 13,000 proteins. By applying these platforms to the same cohort, we systematically assess their performance, identifying ke...
ORGANISM(S): Homo sapiens (Human) 
2025-10-10 | PAD000019 | Pride
Human Affinity proteomics Plasma 
ProteomicsHuman Plasma Discovery Proteomics
This study addresses this gap by conducting a direct comparison of eight platforms, representing both affinity-based and diverse mass spectrometry approaches, and covering over 13,000 proteins. By applying these platforms to the same cohort, we systematically assess their performance, identifying ke...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PAD000022 | Pride
Human Affinity-based Plasma Proteomics 
ProteomicsHuman Plasma Discovery Proteomics
This study addresses this gap by conducting a direct comparison of eight platforms, representing both affinity-based and diverse mass spectrometry approaches, and covering over 13,000 proteins. By applying these platforms to the same cohort, we systematically assess their performance, identifying ke...
ORGANISM(S): Homo sapiens (Human) 
2025-10-09 | PAD000014 | Pride
Human Targeted mass Mass spec Proteomics Plasma Affinity 
ProteomicsHuman Plasma Discovery Proteomics
This study addresses this gap by conducting a direct comparison of eight platforms, representing both affinity-based and diverse mass spectrometry approaches, and covering over 13,000 proteins. By applying these platforms to the same cohort, we systematically assess their performance, identifying ke...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PAD000020 | Pride
Human Mass spec Proteomics Targeted mass spec Plasma Affinity 
ProteomicsPlasma Glycopeptide Enrichment
We have compared three different glycopeptide enrichment techniques (SAX-ERLIC, HILIC, and lectin affinity) and a C18 control to a tryptic digest of proteins from depleted human plasma.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-02 | MSV000082565 | MassIVE
ProteomicsIndividual glycemic responses to carbohydrates vary and reflect underlying metabolic physiology (Olink)
Proteomics data was measured by using the Olink Explore 1536 panel from baseline plasma sample. The project is also supported by Themistocles L Assimes (Stanford University tassimes@stanford.edu) and Fahim Abbasi (Stanford University, fahim@stanford.edu).
ORGANISM(S): Homo sapiens (Human) 
2025-03-31 | PAD000001 | Pride
Affinity proteomics O-link 
ProteomicsA Technical Evaluation of Plasma Proteomics Technologies
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PAD000002 | Pride
Affinity proteomics O-link 
ProteomicsPROMIS-Quan: a novel proteomic method for plasma biomarker quantification
Unbiased proteomic analysis of plasma samples holds the promise to reveal clinically invaluable disease biomarkers. However the tremendous dynamic range of the plasma proteome has so far hampered the identification of such low abundant markers. To overcome this challenge we analyzed the plasma micro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080835 | MassIVE
ProteomicsEvaluation of Olink Reveal Proximity Extension Assay for High-Throughput Proteomics: A Case Study Using NIST SRM 1950 and Spike-In Protein Standards
Plasma proteomics has regained attention in recent years through advancements in mass spectrometry instrumentation and sample preparation, as well as new high-throughput affinity-based technologies. Here, we evaluate the analytical performance of the new Olink Reveal platform, a proximity extension ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PAD000009 | Pride
Affinity proteomics Plasma Olink reveal 
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