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GenomicsEvaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias and copy number variation
Abstract: DNA methylation is an essential epigenetic modification that plays a key role associated with the regulation of gene expression during differentiation but in disease states such as cancer, the DNA methylation landscape is often deregulated. There are now numerous technologies available to...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-24546 | biostudies-arrayexpress
GenomicsAffinity-based controlled release of interleukin-4 from scaffolds via biotin-avidin interactions for immunomodulation
Affinity-based controlled release of interleukin-4 from scaffolds via biotin-avidin interactions for immunomodulation
PRJNA1281087 | ENA
GenomicsSnorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification
Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification
PRJNA1055540 | ENA
GenomicsHigh affinity chromodomains engineered for improved detection of histone modifications and enhanced CRISPR-based gene repression
High affinity chromodomains engineered for improved detection of histone modifications and enhanced CRISPR-based gene repression
PRJNA778779 | ENA
ProteomicsShotgun analysis of proteins in HeLa cells following treatment with polyamine affinity-based probes
HeLa cells were incubated with affinity-based probes, synthetic analogs of endogenous metabolites: putrescine, spermidine, and spermine. Cells were photoirradiated briefly and proteins were extracted, digested with trypsin, and the resulting peptides were labeled with TMT. Proteins were quantified a...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD062452 | Pride
Hela Total protein levels Polyamines Affinity-based probes 
ProteomicsIn-vivo crosslinking based affinity purification-mass spectrometry for targeting intracellular protein-protein interactions
Comprehensive interactome analysis of targeted proteins is of great significance to understand how pro-teins work together for functional regulation. Until now, affinity purification strategy with mass spec-trometry (AP-MS) has been recognized as the most widely used technique for studying protein-p...
ORGANISM(S): Homo Sapiens 
2022-12-01 | PXD038473 |
ProteomicsHeLa cell protein interactome of polyamine affinity-based probes.
HeLa cells were incubated with affinity-based probes designed as synthetic analogs of endogenous metabolites: putrescine, spermidine, and spermine, while a monoamine compound served as a control. Probe-protein interactions were captured in situ using UV-induced crosslinking. After cell lysis, biorth...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD058706 | Pride
Hela Affinity-based probes Polyamines Putrescine Spermidine Protein-metabolite interactions Spermine 
GenomicsB cell-intrinsic IFN-g promotes CD11c+ age-associated B cell differentiation and compromises affinity-based germinal center selection in lupus
B cell-intrinsic IFN-g promotes CD11c+ age-associated B cell differentiation and compromises affinity-based germinal center selection in lupus
PRJNA1132944 | ENA
ProteomicsTAZ (WWTR1) Interactome Analysis using a GBP nanotrap based affinity purification approach
The transcriptional co-activator TAZ (WWTR1) plays a crucial role in regulating gene expression related to cell proliferation, differentiation, and tissue homeostasis, particularly within the Hippo signaling pathway. Since TAZ does not directly bind to DNA, it largely relies on its protein-protein i...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2025-02-11 | PXD060532 | Pride
Mass spectrometry Affinity-purification Skeletal muscle Taz Nanobody 
GenomicsAffinity-independent and nuclease-based strategy to profile R-loop genome-wide [mESC]
Affinity-independent and nuclease-based strategy to profile R-loop genome-wide [mESC]
PRJNA1070626 | ENA
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