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MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
MetabolomicsSpermine is an endogenous iron chelator that inhibits ferroptosis

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation. Here, we identify spermine—a polyamine derived from spermidine—as an endogenous iron chelator that directly suppresses ferroptosis. Integrating metabolomics, stable isotope tracing, and biophysical studies of the in...

2025-11-11 | MTBLS13306 | MetaboLights
TranscriptomicsEffect of spermine oxidase overexpression on skeletal muscle mRNA expression.
For additional details see Bongers et al, Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy . Am J Physiol Endocrinol Metab. 2014 [under review] Bilateral tibialis anterior muscles of C57BL/6 m...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-63006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Francisella tularensis to spermine
Francisella tularensis LVS was grown in MH broth in the presence or absence of 200uM spermine. RNA was harvasted from overnight (16 hour) cultures and processed for microarray hybridization.
ORGANISM(S): Francisella tularensis 
2009-11-20 | E-MEXP-2327 | biostudies-arrayexpress
ProteomicsMass spectrometry distinguishes putrescine, spermidine, and spermine covalently attached to proteins
Bacterial and mammalian cells are rich in putrescine, spermidine and spermine. Polyamines can be incorporated into proteins in vitro. Very few naturally occurring polyaminated proteins have been identified. Bovine albumin and the recombinant universal stress protein from Francisella tularensis we...
ORGANISM(S): Bos taurus (Bovine) 
2024-02-27 | PXD046396 | Pride
Polyamine Universal stress protein Transglutaminase Mass spectrometry Manual evaluation Carbodiimide Albumin 
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae mutant delta-spe3 delta-fms1 after spermidine treatment
The naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have prominent regulatory roles in cell division and growth, precise molecular and cellular functions are not well established in vivo. In this work we have performed a microarray e...
ORGANISM(S): Saccharomyces cerevisiae 
2009-09-05 | E-GEOD-15269 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT)
Type 2 diabetes is a complex disorder due to defects in insulin secretion and insulin action. Therefore, we investigated mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT) have reduced amount of white adipose tissue, high basal metabolic rate, improved glucose tolerance, high insul...
ORGANISM(S): Mus musculus 
2007-04-25 | E-MEXP-165 | biostudies-arrayexpress
ProteomicsProteomics analyses reveal the novel targets of spermine alleviating diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is one of the most serious complications of diabetes. Recent cardiology studies suggest that spermine has cardioprotective effect. Here, we used proteomics analyses to reveal the underlying research target in type 2 diabetic mouse model treated with spermine. Left ventr...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD036364 | Pride
Diabetic cardiomyopathy  spermine  proteomic analysis  bioinformatic db/db mouse 
GenomicsCellular spermine targets JAK1 to restrain cytokine-mediated autoimmunity
Cellular spermine targets JAK1 to restrain cytokine-mediated autoimmunity
PRJNA905367 | ENA
GenomicsSpermine-induced gene expression change in human macrophages
Spermine-induced gene expression change in human macrophages
PRJNA1108626 | ENA
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