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MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Given that Aflatoxin B1 exposure drives 5% to 28% of global hepatocellular carcinoma cases, the critical paucity of effective interventions for Aflatoxin B1-induced liver injury represents an urgent need. Here, we discover that a cereal-derived polyph...

2026-08-13 | MTBLS13667 | MetaboLights
MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Aflatoxin B1 (AFB1)-induced hepatic inflammation poses severe global health burdens with limited interventions. Here, we demonstrated that ferulic acid (FA), a cereal-derived polyphenol, alleviated AFB1 hepatotoxicity by remodeling gut microbiota and activating microbial tryptopha...

2026-08-14 | MTBLS12942 | MetaboLights
TranscriptomicsDifferential expression of Aspergillus genes during the induction of aflatoxin biosynthesis
Gene expression analysis of A. parasiticus grown under conditions conducive and nonconductive for aflatoxin production was evaluated using glass slide microarrays containing the 753 ESTs. A complex regulatory network governs the biosynthesis of aflatoxin. While several genes involved in aflatoxin ...
ORGANISM(S): Aspergillus parasiticus 
2003-01-15 | E-GEOD-204 | biostudies-arrayexpress
TranscriptomicsDNA methylome analysis in infants from The Gambia / Aflatoxin / Seasonality study
Genome wide DNA methylation profiling in infant's blood from a mother/child cohort in The Gambia. The main variables of the analyses were the intra-uterine exposure to aflatoxin B1 (AFB1) and the season of conception. The Illumina Infinium HumanMethylation 450k Beadchip was used to obtain DNA methyl...
ORGANISM(S): Homo sapiens 
2015-04-18 | E-GEOD-59592 | biostudies-arrayexpress
TranscriptomicsGenes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers
Aflatoxins are carcinogenic fungal secondary metabolites. Levels of aflatoxins in agricultural commodities are stringently regulated by many countries. A cluster of genes is responsible for aflatoxin biosynthesis by Aspergillus flavus and other closely related species. Expression of the clustered af...
ORGANISM(S): Aspergillus flavus 
2010-05-26 | E-GEOD-8185 | biostudies-arrayexpress
TranscriptomicsYeast Genomic Expression Patterns of Wild-type and PTC1 null mutant in Response to Aflatoxin B1 (AFB1)
The evaluation of the toxicity of Aflatoxin B1 using yeast gene expressions. Two yeast strains; parental BY4743 and PTC1 mutant, were used for this study. SDS was used to raise the penetration of the yeast cell membrane. Two conditions are compared with three replicates each. Both strains were grown...
ORGANISM(S): Saccharomyces cerevisiae 
2010-04-12 | E-GEOD-17367 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse livers of adult and newborn animal response to Aflatoxin B1
Susceptibility to the hepatocarcinogen Aflatoxin B1 (AFB1) varies among species and with age. Mice are refractory to carcinogenic and toxic effects of AFB1; however, B6C3F1 mice show transient sensitivity if dosed shortly after birth. We compared age-related differences in gene expression and trans...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-4740 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis for high- and low-aflatoxin-yield Aspergillus flavus strains isolated from natural environments
The molecular mechanisms underlying aflatoxin production have been well-studied in strains of the fungus Aspergillus flavus (A. flavus) under artificial conditions. However, aflatoxin biosynthesis has rarely been studied in natural isolates of A. flavus strains. In the present study, tandem mass tag...
ORGANISM(S): Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) 
2022-02-17 | PXD027517 | Pride
Natural environments Aspergillus flavus Quantification proteome Aflatoxin production 
ProteomicsCorrelation of isolate-specific oxidative stress responses at the protein level in Aspergillus flavus with aflatoxin production capability
Aspergillus flavus is a pathogen of corn, peanut, and other crops which produces carcinogenic mycotoxins known as aflatoxins. Previous studies have shown that drought stress results in exacerbated aflatoxin production. Drought-associated oxidative stress caused by reactive oxygen species (ROS) is su...
ORGANISM(S): Aspergillus flavus 
2018-02-27 | PXD007164 | Pride
Drought stress Aspergillus flavus Itraq proteomics Aflatoxin Oxidative stress 
TranscriptomicsGAP aflR- vs WT timecourse
The carcinogen aflatoxin is synthesized by a cluster of genes that are regulated by the transcriptional factor, AflR. Most, but not all of these genes, have a consensus binding site for AflR in their 5’ untranslated region. Because aflR resides within the biosynthetic cluster, is has been sugges...
ORGANISM(S): Aspergillus parasiticus 
2010-06-10 | E-GEOD-2709 | biostudies-arrayexpress
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