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MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Aflatoxin B1 (AFB1)-induced hepatic inflammation poses severe global health burdens with limited interventions. Here, we demonstrated that ferulic acid (FA), a cereal-derived polyphenol, alleviated AFB1 hepatotoxicity by remodeling gut microbiota and activating microbial tryptopha...

2026-08-14 | MTBLS12942 | MetaboLights
TranscriptomicsGenes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers
Aflatoxins are carcinogenic fungal secondary metabolites. Levels of aflatoxins in agricultural commodities are stringently regulated by many countries. A cluster of genes is responsible for aflatoxin biosynthesis by Aspergillus flavus and other closely related species. Expression of the clustered af...
ORGANISM(S): Aspergillus flavus 
2010-05-26 | E-GEOD-8185 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Aspergillus genes during the induction of aflatoxin biosynthesis
Gene expression analysis of A. parasiticus grown under conditions conducive and nonconductive for aflatoxin production was evaluated using glass slide microarrays containing the 753 ESTs. A complex regulatory network governs the biosynthesis of aflatoxin. While several genes involved in aflatoxin ...
ORGANISM(S): Aspergillus parasiticus 
2003-01-15 | E-GEOD-204 | biostudies-arrayexpress
ProteomicsCorrelation of isolate-specific oxidative stress responses at the protein level in Aspergillus flavus with aflatoxin production capability
Aspergillus flavus is a pathogen of corn, peanut, and other crops which produces carcinogenic mycotoxins known as aflatoxins. Previous studies have shown that drought stress results in exacerbated aflatoxin production. Drought-associated oxidative stress caused by reactive oxygen species (ROS) is su...
ORGANISM(S): Aspergillus flavus 
2018-02-27 | PXD007164 | Pride
Drought stress Aspergillus flavus Itraq proteomics Aflatoxin Oxidative stress 
ProteomicsQuantitative proteomic analysis for high- and low-aflatoxin-yield Aspergillus flavus strains isolated from natural environments
The molecular mechanisms underlying aflatoxin production have been well-studied in strains of the fungus Aspergillus flavus (A. flavus) under artificial conditions. However, aflatoxin biosynthesis has rarely been studied in natural isolates of A. flavus strains. In the present study, tandem mass tag...
ORGANISM(S): Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) 
2022-02-17 | PXD027517 | Pride
Natural environments Aspergillus flavus Quantification proteome Aflatoxin production 
TranscriptomicsGAP_Culture_conditions
Gene expression analysis of A. parasiticus grown under conditions conducive and nonconductive for aflatoxin production was evaluated using glass slide microarrays containing 765 ESTs. Aflatoxins (AF) produced by Aspergillus flavus and A. parasiticus are responsible for approximately $270M in losses ...
ORGANISM(S): Aspergillus flavus 
2010-06-10 | E-GEOD-1649 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis reveals novel regulatory genes associated with the non-aflatoxigenic Aspergillus parasiticus mutants obtained by 5-azacytosine treatment or serial mycelial transfer
Aflatoxins are carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Repeated serial mycelial transfer or treatment of A. parasiticus with 5-azacytidine produced mutants with a fluffy phenotype and loss of aflatoxin production. To understand how the...
ORGANISM(S): Aspergillus parasiticus 
2011-12-31 | E-GEOD-30756 | biostudies-arrayexpress
TranscriptomicsAspergillus flavus transcriptome under different temperature conditions
To better understand the effect of temperature on mycotoxin biosynthesis, RNA-Seq technology was used to profile the Aspergillus flavus transcriptome under different temperature conditions. This approachallowed us to quantify transcript abundance for over 80% of fungal genes including 1,153 genes th...
ORGANISM(S): Aspergillus flavus 
2011-06-16 | E-GEOD-30031 | biostudies-arrayexpress
TranscriptomicsGAP aflR- vs WT timecourse
The carcinogen aflatoxin is synthesized by a cluster of genes that are regulated by the transcriptional factor, AflR. Most, but not all of these genes, have a consensus binding site for AflR in their 5’ untranslated region. Because aflR resides within the biosynthetic cluster, is has been sugges...
ORGANISM(S): Aspergillus parasiticus 
2010-06-10 | E-GEOD-2709 | biostudies-arrayexpress
TranscriptomicsEffect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis
Aspergillus flavus is the major producer of carcinogenic aflatoxins in crops worldwide. Natural populations of A. flavus show tremendous variation in aflatoxin production some of which can be attributed to extreme environmental conditions (e.g., drought), differential regulation of the aflatoxin bi...
ORGANISM(S): Aspergillus flavus 
2012-03-07 | E-GEOD-27484 | biostudies-arrayexpress
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