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TranscriptomicsAblation of Dicer from murine Schwann cells increases their proliferation while blocking myelination
The myelin sheaths that surround the thick axons of the peripheral nervous system are produced by the highly specialized Schwann cells. Differentiation of Schwann cells and myelination occur in discrete steps. Each of these requires coordinated expression of specific proteins in a precise sequence, ...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-22023 | biostudies-arrayexpress
TranscriptomicsImpact of Prnp genetic ablation in the hippocampus transcriptome of congenic B6.129-PrnpZH1/ZH1 or coisogenic C57BL/6-PrnpZH3/ZH3 mice
To study the effect of Prnp genetic ablation on different aspects of RNA metabolism, we performed RNA sequencing of the hippocampus of wild-type C57BL/6J, congenic B6.129-PrnpZH1/ZH1 and coisogenic C57BL/6J-PrnpZH3/ZH3 mice. We analyzed differential gene expression, exon usage and RNA editing. RNA s...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-75510 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary splenocytes enriched or depleted of follicular dendritic cells to study the events leading to maturation of follicular dendritic cells and lymphoid germinal centers.
Comparison of follicular dendritic cell-enriched versus -depleted splenocytes. Affinity maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular dendritic cells (...
ORGANISM(S): Mus musculus 
2007-09-21 | E-GEOD-2123 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse
Affymetrix genechip profiling analsysis (MOE430A and MOE430B) of murine neuroblastoma cells infected with either RML prion strain or mock brain homogenate Experiment Overall Design: Parental N2a cells were split into 6 aliquots, 3 of which were infected with RML prions and 3 of which were mock-infec...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7229 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lymph nodes treated with soluble lymphotoxin-beta receptor for 0, 1, 2, 3, 27 and 35 days
treatment of mesenteric lymph nodes with soluble lymphotoxin-beta receptor for 0,1,2,3,27 and 35 days
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2124 | biostudies-arrayexpress
UnknownLoss of PIKfyve drives the spongiform degeneration in prion diseases.
Not available
S-SCDT-EMM-2021-14714P | biostudies-other
TranscriptomicsTime course of prion infected (RML) and globular domain ligands (POM1) in cultured organotypic cerebellar slices (COCS)
Cultured organotypic cerebellar slices were exposed for different time points with either prions (RML) versus non-infectious brain homogenate (NBH) or ligands to the globular domain of the prion protein (POM1) vs IgG We used microarrays to characterize the temporal response of two inducers prion pro...
ORGANISM(S): Mus musculus 
2015-01-22 | E-GEOD-65147 | biostudies-arrayexpress
UnknownProtective anti-prion antibodies in human immunoglobulin repertoires
Not available
S-SCDT-EMM-2020-12739 | biostudies-other
UnknownStructure-function relationship of alpha-synuclein fibrils derived from distinct synucleinopathies
Not available
S-SCDT-10_1038-S44320-026-00199-5 | biostudies-other
UnknownArrayed Genome-Wide Perturbation Screen Identifies Hnrnpk As Rate-Limiting for Prion Propagation
Not available
S-SCDT-10_15252-EMBJ_2022112338 | biostudies-other
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