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ProteomicsA phosphoproteomic comparison of B-RAFV600E and MKK1/2 inhibitors in melanoma cells, part 1
To provide insight into the molecular nature of the clinical responses seen with MAPK pathway inhibition in melanoma, we used quantitative mass spectrometry to characterize the inhibitor-dependent phosphoproteome of human melanoma cells treated with the B-RAFV600E inhibitor PLX4032 (vemurafenib) and...
ORGANISM(S): Homo sapiens (Human) 
2016-02-25 | PXD001560 | Pride
Human Melanoma Azd6244 Silac Plx4032 
ProteomicsCooperative polarization of MCAM/CD146 and ERM family proteins in melanoma
The WRAMP structure is a protein network associated with tail-end actomyosin contractility, membrane retraction, and directional persistence during cell migration. A marker of WRAMP structures is melanoma cell adhesion molecule (MCAM) which dynamically polarizes to the cell rear. However, factors th...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047722 | Pride
Wnt5a Wramp Mcam Erm 
ProteomicsSpecificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells, experiment 1 of 2
We used phosphoproteomics to compare the responses of the ERK1/2 inhibitors, SCH772984 and GDC0994, and the MKK1/2 inhibitor, trametinib. These are compared with responses to the MKK1/2 inhibitor, selumetinib (AZD6244), previously measured by our lab in the same metastatic melanoma cell line. In thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007620 | Pride
Human Melanoma Silac Selumetinib Trametinib Gdc0994 Sch772984 
ProteomicsSpecificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells, experiment 2 of 2
We used phosphoproteomics to compare the responses of the ERK1/2 inhibitors, SCH772984 and GDC0994, and the MKK1/2 inhibitor, trametinib. These are compared with responses to the MKK1/2 inhibitor, selumetinib (AZD6244), previously measured by our lab in the same metastatic melanoma cell line. In thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007621 | Pride
Human Melanoma Silac Selumetinib Trametinib Gdc0994 Sch772984 
ProteomicsA phosphoproteomic comparison of B-RAFV600E and MKK1/2 inhibitors in melanoma cells, part 2
. To provide insight into the molecular nature of clinical responses to B-RAF(V600E) and MKK1/2 inhibition, we used quantitative mass spectrometry to characterize the inhibitor-dependent phosphoproteome of human melanoma cells treated with the B-RAF(V600E) inhibitor PLX4032 (vemurafenib) and the MKK...
ORGANISM(S): Homo sapiens (Human) 
2016-02-25 | PXD001563 | Pride
Azd6244 Melanoma Silac Plx4032 
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