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ProteomicsA phosphoproteomic comparison of B-RAFV600E and MKK1/2 inhibitors in melanoma cells, part 1
To provide insight into the molecular nature of the clinical responses seen with MAPK pathway inhibition in melanoma, we used quantitative mass spectrometry to characterize the inhibitor-dependent phosphoproteome of human melanoma cells treated with the B-RAFV600E inhibitor PLX4032 (vemurafenib) and...
ORGANISM(S): Homo sapiens (Human) 
2016-02-25 | PXD001560 | Pride
Human Melanoma Azd6244 Silac Plx4032 
ProteomicsCooperative polarization of MCAM/CD146 and ERM family proteins in melanoma
The WRAMP structure is a protein network associated with tail-end actomyosin contractility, membrane retraction, and directional persistence during cell migration. A marker of WRAMP structures is melanoma cell adhesion molecule (MCAM) which dynamically polarizes to the cell rear. However, factors th...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047722 | Pride
Wnt5a Wramp Mcam Erm 
ProteomicsSpecificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells, experiment 2 of 2
We used phosphoproteomics to compare the responses of the ERK1/2 inhibitors, SCH772984 and GDC0994, and the MKK1/2 inhibitor, trametinib. These are compared with responses to the MKK1/2 inhibitor, selumetinib (AZD6244), previously measured by our lab in the same metastatic melanoma cell line. In thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007621 | Pride
Human Melanoma Silac Selumetinib Trametinib Gdc0994 Sch772984 
ProteomicsSpecificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells, experiment 1 of 2
We used phosphoproteomics to compare the responses of the ERK1/2 inhibitors, SCH772984 and GDC0994, and the MKK1/2 inhibitor, trametinib. These are compared with responses to the MKK1/2 inhibitor, selumetinib (AZD6244), previously measured by our lab in the same metastatic melanoma cell line. In thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007620 | Pride
Human Melanoma Silac Selumetinib Trametinib Gdc0994 Sch772984 
ProteomicsA phosphoproteomic comparison of B-RAFV600E and MKK1/2 inhibitors in melanoma cells, part 2
. To provide insight into the molecular nature of clinical responses to B-RAF(V600E) and MKK1/2 inhibition, we used quantitative mass spectrometry to characterize the inhibitor-dependent phosphoproteome of human melanoma cells treated with the B-RAF(V600E) inhibitor PLX4032 (vemurafenib) and the MKK...
ORGANISM(S): Homo sapiens (Human) 
2016-02-25 | PXD001563 | Pride
Azd6244 Melanoma Silac Plx4032 
ProteomicsVariable Thresholds for Phosphorylation Targets of the ERK Signaling Pathway
Cell fates regulated by ERK/MAP kinases respond to different thresholds of signaling strength. In mammalian cells, conditions that activate ERK to submaximal levels are sufficient for proliferation, survival and transformation, while stimuli that activate ERK to very high levels often lead to cell d...
ORGANISM(S): Homo Sapiens 
2026-02-25 | PXD070673 | panorama
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