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MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays after inhibition with FSG67 and Triacsin C)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6083 | MetaboLights
MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Targeted lipidomics assay without inhibition)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6084 | MetaboLights
MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays without inhibition)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6082 | MetaboLights
UnknownData and model considerations for estimating time-varying functional connectivity in fMRI.
Not available
S-EPMC9361391 | biostudies-literature
MetabolomicsUncovering the Complexity of the Yeast Lipidome by Means of nLC/NSI-MS/MS
Saccharomyces cerevisiae is a eukaryotic model organism widely used for the investigation of fundamental cellular processes and disease mechanisms. Consequently, the lipid landscape of yeast has been extensively investigated and up to this day the lipidome is considered as rather basic. Here, we use...
2021-01-08 | MTBLS2119 | MetaboLights
UnknownSpatial and temporal patterns of agrometeorological indicators in maize producing provinces of South Africa.
Not available
S-EPMC9287399 | biostudies-literature
ProteomicsSIMPLEX enriches hydrophobic and lipidated proteins in membrane proteomics experiments
Synaptosome (Syn) and synaptic junctions (SJ) are widely used in omics experiments to investigate protein content and networks of synapses. Synapses are a neuronal compartment wit a high lipid content. Liquid-liquid extraction (LLE), typically used in lipidomics, shows great potential for multiomics...
ORGANISM(S): Rattus rattus (Black rat) 
2025-09-08 | PXD058138 | Pride
Liquid-liquid extraction Synaptosomes Domains Synaptic junctions Membrane-enriched sample Transmembrane proteins 
ProteomicsSIMPLEX a multimolecular omics approach for systems biology
We introduce here SIMPLEX (SImultaneous Metabolite, Protein, Lipid EXtraction procedure), a unique strategy for the quantitative investigation of lipids, metabolites and proteins. SIMPLEX offers a fundamental turn in study design since multimolecular classes can be accessed in parallel from one samp...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-08 | PXD002101 | Pride
Pparg signaling Metabolites Proteomics Lipidomics 
UnknownConsecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion.
Not available
S-EPMC4959269 | biostudies-literature
ProteomicsMulti-omics reveals the lipid inventory of synaptic junctions and altered lipid signaling in environmental enrichment
Membrane lipids are essential components of synaptic junctions that have key functions in neurotransmission. In the first part of the study, we provide a quantitative lipid inventory of mouse and rat synaptic junctions. We next used a simultaneous multi-omics extraction and analysis workflow termed ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2023-11-14 | PXD017997 | Pride
Enriched environment Lipidomics Multi-omics Endocannabinoid signaling Synaptic junctions 
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