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TranscriptomicsCut in Drosophila airway remodeling
Effect of the amount of the transcription factor Cut on the expression profile of airway progenitor cells in Drosophila third instar larvae. Populations of airway progenitor cells with different Cut abundance (wild-type and genetically-manipulated) were used for expression profiling.
ORGANISM(S): Drosophila melanogaster 
2013-02-19 | E-MEXP-3831 | biostudies-arrayexpress
TranscriptomicsPhenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus
We report the application of RNA sequencing technology for high-throughput profiling of gene expression responses to human rhinovirus infection at 24 hours in air-liquid interface human airway epithelial cell cultures derived from 6 asthmatic and 6 non-asthmatic donors. RNA-seq analysis identified ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-61141 | biostudies-arrayexpress
TranscriptomicsPost-exposure effect of whole cigarette smoke on in vitro 3D human airway epithelial tissues from large and small epithelial cells
Chronic obstructive pulmonary disease (COPD) is a disease state characterized by poorly reversible, limited airflow that is usually both progressive and associated with an abnormal inflammatory response of the lung. One cause of COPD is chronic exposure to airborne materials such as cigarette smoke ...
ORGANISM(S): Homo sapiens 
2020-12-24 | E-MTAB-8680 | biostudies-arrayexpress
ProteomicsGu-Ben-Fang-Xiao decoction ameliorates airway remodeling by regulating the PI3K/AKT signaling pathway mediated by RTN4 in a chronic remission asthma murine model
Airway remodeling is a main pathological feature of asthma. The current therapy for asthma is mainly targeted for reducing inflammation, not particularly for airway remodeling. Herein, developing alternative and more effective therapy to attenuate remodeling is worthy of further study. Gu-Ben-Fang-X...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020711 | Pride
Rtn4 Pi3k/akt pathway Gu-ben-fang-xiao decoction Chronic remission asthma Airway remodeling 
ProteomicsSystematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights Into Pathogenesis Of RSV-Induced Lower Respiratory Tract Infections
Lower respiratory tract infections (LRTI) from human Respiratory Syncytial Virus (RSV) are a significant cause of morbidity in children. A component of LRTI pathogenesis is due to signals generated by infected lower airway cells that alter lymphocyte populations and trigger airway remodeling. To ob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080867 | MassIVE
TranscriptomicsGene expression profiling of mesenchyme-derived cell populations in the human airways
Mesenchyme-derived cells in the human airway wall including airway smooth muscle cells, fibroblasts and myofibroblasts are known to play important roles in airway remodeling. The lack of specific phenotypic markers makes it difficult to define these cell populations in primary cultures. The objectiv...
ORGANISM(S): Homo sapiens 
2010-04-01 | E-GEOD-18038 | biostudies-arrayexpress
Transcriptomics8-Oxoguanine DNA glycosylase-1 DNA repair-signaling induces gene expression associated to airway remodeling
Purpose: The aim of this study is to test whether global gene expression induced by multiple challenges with OGG1-BER product 8-oxoG in mouse airways is linked to airway remodeling. Methods: RNAs extracted from individual mouse lungs (experimental group: n=5) were pooled and a total 1 ?g RNA was use...
ORGANISM(S): Mus musculus 
2015-07-03 | E-GEOD-65031 | biostudies-arrayexpress
TranscriptomicsGenomic differences distinguish the myofibroblast phenotype of distal lung from airway fibroblasts
ABSTRACT Primary human distal lung/parenchymal fibroblasts (DLF) exhibit a different phenotype from airway fibroblasts (AF), including the expression of high levels of a-smooth muscle actin (a-SMA). The scope of the differences and the mechanisms driving them are unknown. To determine whether disti...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-27335 | biostudies-arrayexpress
UnknownHedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.
Not available
S-EPMC8079715 | biostudies-literature
GenomicsThe Central Role of Gasdermin D in Asthmatic Airway Inflammation and Remodeling
The Central Role of Gasdermin D in Asthmatic Airway Inflammation and Remodeling
PRJNA1051164 | ENA
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