Sort   by:  
 Page size 
ProteomicsMass-spectrometry analysis of vehicle or AKB-9778 treated FOXF2KO and WT human endothelial cells
To validate our results on Foxf2 related Tie2 signaling and explore their transferability to human cells, we studied human iPSC-derived endothelial cells (iECs). FOXF2KO and WT iECs (González-Gallego et al., in preparation) were treated with AKB-9778 or vehicle and assessed by proteomics. Similar to...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD051855 | Pride
Small vessel disease Foxf2 Akb-9778 Tie2 Endothelial cell 
UnknownThe VE-PTP Inhibitor AKB-9778 Improves Antitumor Activity and Diminishes the Toxicity of Interleukin 2 (IL-2) Administration.
Not available
S-EPMC8088541 | biostudies-literature
ProteomicsMass-spectrometry analysis of isolated brain vessels from vehicle treated Foxf2iECKO, vehicle-treated Ctrl, and AKB-9778 treated Foxf2iECKO mice
To further characterize the role of endothelial Foxf2 in the maintenance of vascular function and examine a possible mediating effect of Tie2 signaling, we pharmacologically modulated Tie2 activity in mice and performed subsequent in vivo analyses together with studies on isolated brain vessels. Spe...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-02 | PXD051839 | Pride
Small vessel disease Foxf2 Tie2 Microvessel 
UnknownA Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure.
Not available
S-EPMC7735951 | biostudies-literature
UnknownTargeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.
Not available
S-EPMC4191011 | biostudies-literature
UnknownEffects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.
Not available
S-EPMC3748004 | biostudies-literature
UnknownLipid Nanoparticle Delivery System for Normalization of Tumor Microenvironment and Tumor Vascular Structure.
Not available
S-EPMC11811622 | biostudies-literature
UnknownInterfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin.
Not available
S-EPMC4689167 | biostudies-literature
UnknownTie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
Not available
S-EPMC8564889 | biostudies-literature
UnknownThe stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling.
Not available
S-EPMC12880920 | biostudies-literature
Sort   by:  
 Page size