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GenomicsDevelopmental Regulation and Individual Differences of Neuronal Epigenomes in the Prefrontal Cortex
We report global distribution of trimethylated Histone H3 Lysine 4 (H3K4me3) in human prefrontal cortex neurons at different ages Neuronal nuclei from human prefrontal cortex were isolated by FACS. Regions marked by H3K4me3 were identified by chromatin immunoprecipiation followed by deep sequencing.
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-21172 | biostudies-arrayexpress
GenomicsH3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples
Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder resulting from expansion in the number of CAG repeats in the coding region of exon 1 of the Huntingtin (HTT) gene. One of the most widely studied chromatin modifications is trimethylated lysine 4 of histone 3 (H3K4me3). ...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-68952 | biostudies-arrayexpress
ProteomicsNeuronal Nsun2 deficiency is associated with codon-specific epitranscriptomic dysregulation of Gly-tRNAs and corresponding proteomic shift impacting synaptic signaling and behavior
The role of transfer (t)RNA cytosine methyl-transferases as epitranscriptomic regulators of brain proteomes remains unexplored. We report that fear memory and antidepressant-like behaviors are highly sensitive to bi-directional changes in Nsun2 tRNA methyltransferase activity in prefrontal cortex (P...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-02 | PXD023437 | Pride
Nsun2 Tmt Neurons 
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