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TranscriptomicsExpression data from Evi1-transduced primary bone marrow cells
Evi1 is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders. Particularly, high Evi1 expression defines one of the largest clusters in acute myeloid leukemia and is significantly associated with extremely poor prognosis. Improvement of the t...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22434 | biostudies-arrayexpress
ProteomicsNotoginsenoside R1 regulates ischemic myocardial lipid metabolism through activating AKT/mTOR signaling pathway
Radix notoginseng is widely used to treat ischemic heart disease in China and other Asian countries, and notoginsenoside R1 (NGR1) is its characteristic and large-amount ingredient. However, the potential molecular mechanisms of NGR1 improving ischemic heart diseases are unclear. Our results reveale...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-12 | PXD032814 | Pride
Notoginsenoside r1  ischemic heart disease  cardioprotection  lipid metabolism  akt/mtor pathway 
GenomicsNootkatone preferentially suppressed the AKT/mTOR signaling in activated fibroblasts
Nootkatone preferentially suppressed the AKT/mTOR signaling in activated fibroblasts
PRJNA1483477 | ENA
TranscriptomicsAkt-Induced Mitochondrial Dysfunction in the Heart
Sustained Akt activation induces cardiac hypertrophy (LVH), which may lead to heart failure. This study tested the hypothesis that Akt activation contributes to mitochondrial dysfunction in pathological LVH. Akt activation induced LVH and progressive repression of mitochondrial fatty acid oxidation ...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-63848 | biostudies-arrayexpress
ProteomicsAlt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
While thousands of previously unannotated small and alternative open reading frames (alt-ORFs) have recently been revealed in the human genome, the functions of only a handful are currently known, leaving open the question of their biological significance as a class. Using a proteomic strategy for d...
ORGANISM(S): Homo sapiens (Human) 
2020-12-07 | PXD018268 | Pride
Human microprotein alt-protein phosphoproteomics 
MetabolomicsFerritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights
GenomicsCardiomyocyte S1pr1 regulates cardiac regeneration via AKT/mTOR signaling pathway
Cardiomyocyte S1pr1 regulates cardiac regeneration via AKT/mTOR signaling pathway
PRJNA1009408 | ENA
ProteomicsTargeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Circulating tumor cells (CTCs) play an important role in metastasis formation. Aberrant signaling of oncogenic pathways (e.g. PI3K/AKT/mTOR pathway) drives tumor progression. In this work, the susceptibility of the colon cancer CTC derived cell line, CTC-MCC-41, for AKT and mTOR inhibitors was evalu...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD054001 | Pride
Ctcs  pi3k/akt/mtor pathway  akt isoforms  xenotransplantation model  proteomics  mk2206  rad001  colorectal carcinoma  drug sensitivity assays  dual targeting  personalized medicine  targeted therapy 
ProteomicsOptimized isolation of protein on chromatin (iPOC) strategy reveals the dynamics of chromatin composition upon inhibition of PI3K/AKT/mTOR signaling
Signaling pathways play critical roles in executing and controlling important biological processes within cells. The dysregulation of signaling pathways modulates chromatin modifications to regulate the epigenome, thereby contributing to tumorigenesis and metastasis Despite their cancer-related impo...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045235 | Pride
Pi3k/akt/mtor Lc/ms-ms Dna binding proteomics 
ProteomicsSynergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 and KIT. FLT3 and KIT mutations are associated with poor...
ORGANISM(S): Mus Musculus 
2023-01-26 | PXD030214 | panorama
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