Sort   by:  
 Page size 
MetabolomicsDietary High Fiber and N-Carbamylglutamate Enhance Sow Reproductive Performance via Modulating Lactobacilli, Lipid Metabolites, and the PI3K-Akt Signaling Pathway

Background Both high fiber diet and N-Carbamylglutamate (NCG) individually contributes to improve reproductive efficiency in sow. However, the potential synergistic effects and the underlying mechanisms are not well-understood. Here, Landrace x Yorkshire sows were selected to investigate the syne...

2025-12-16 | MTBLS13516 | MetaboLights
ProteomicsProteomics dataset of knockdown of AKT3 on protein expression and function in female germline stem cells
Female germline stem cells (FGSCs) are adult stem cells capable of self-renewal and differentiation into mature oocytes. AKT3, a member of the AKT kinase family, plays crucial roles in multiple cellular processes, such as proliferation, migration, and apoptosis. However, the mechanism by which AKT3 ...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-15 | PXD054663 | Pride
Fgscs  akt3 Proteomics  pathway analysis 
GenomicsAXL-TBK1 driven AKT3 activation promotes metastasis
AXL-TBK1 driven AKT3 activation promotes metastasis
PRJNA1148385 | ENA
TranscriptomicsGene expression profiling of Akt3 over-expressing breast cancer cells after estrogen and tamoxifen treatment
The aim of this study is to identify the differentially expressed genes in upon Akt3 over-expression after estrogen and tamoxifen treatment. RNA were extracted from three independently treated respective breast cancer cell lines and processed for further microarray experiments.
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-34291 | biostudies-arrayexpress
TranscriptomicsAXL-TBK1 driven AKT3 activation promotes metastasis
The receptor tyrosine kinase AXL promotes tumor progression, metastasis and therapy resistance through the induction of epithelial-mesenchymal transition (EMT). Here, we report that activation of AXL results in TANK-binding kinase 1 (TBK1) phosphorylation, subsequent TBK1-dependent phosphorylation o...
ORGANISM(S): Homo sapiens 
2024-12-17 | GSE274874 | GEO
ProteomicsAKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope
Unlike other signaling proteins, cellular stimulation does not induce nuclear AKT accumulation. While AKT1 is cytoplasmic, shifting to the plasma membrane upon stimulation, AKT2 is mainly nuclear. AKT3 in cancer cells is constitutively active at the nuclear envelope, where it phosphorylates TSC2 and...
ORGANISM(S): Homo sapiens (Human) 
2022-12-11 | PXD037856 | Pride
Nuclear envelope Akt3 Phosphorylation 
GenomicsMechanism of RUNX1 targeted AKT3 regulated alveolar procoagulant fibrinolytic inhibition in ARDS
Mechanism of RUNX1 targeted AKT3 regulated alveolar procoagulant fibrinolytic inhibition in ARDS
PRJNA992179 | ENA
TranscriptomicsGenomically amplified Akt3 activates DNA repair pathway and promotes glioma progression
Akt is a robust oncogene that plays key roles in the development and progression of many cancers, including glioma. We evaluated the differential propensities of the Akt isoforms toward progression in the well-characterized RCAs/Ntv-a mouse model of PDGFB-driven low grade glioma. A constitutively ac...
ORGANISM(S): Mus musculus 
2015-02-24 | GSE66177 | GEO
TranscriptomicsGenomically amplified Akt3 activates DNA repair pathway and promotes glioma progression
Akt is a robust oncogene that plays key roles in the development and progression of many cancers, including glioma. We evaluated the differential propensities of the Akt isoforms toward progression in the well-characterized RCAs/Ntv-a mouse model of PDGFB-driven low grade glioma. A constitutively ac...
ORGANISM(S): Mus musculus 
2015-02-24 | E-GEOD-66177 | biostudies-arrayexpress
UnknownVEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase.
Not available
S-EPMC2518259 | biostudies-literature
Sort   by:  
 Page size