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MetabolomicsMetabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines
An emerging method to help elucidate the mode of action of experimental drugs is to use untargeted metabolomics of cell-systems. The interpretations of such screens are however complex and more examples with inhibitors of known targets are needed. Here two T-cell lines were treated with an inhibitor...
2018-12-04 | MTBLS789 | MetaboLights
MetabolomicsAspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function. Here we use metabolomic, genetic and structural approaches to show that Rv3722c is the primary aspartate aminotransferase of M. tuberculosis...

2020-05-01 | MTBLS1559 | MetaboLights
ProteomicsInteractome of alanine:glyoxylate aminotransferase polimorphic forms
This dataset includes raw data on the interactome of two polymorphic forms of alanine:glyoxylate aminotransferase (AGT), the major allele, AGT-Ma and the minor one AGT-Mi. Theproteins were expressed in HEK293 cells and the interactome was analysed using co-immunoprecipitation mass spectrometry (IP-M...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD025661 | Pride
Alanine:glyoxylate aminotransferase Human Hek293 Interactome 
TranscriptomicsNitrogen-efficient rice over-expressing alanine aminotransferase
Oryza sativa cv. Nipponbare was engineered to over-express a barley alanine aminotransferase (alaAT) gene using the promoter (OsANT1) from a rice aldehyde dehydrogenase gene that expresses in roots. We are using biotechnology to improve the nitrogen use efficiency of rice by over-expressing alaAT in...
ORGANISM(S): Oryza sativa 
2012-07-27 | GSE39687 | GEO
ProteomicsProteomic characterization of infant and adult ornithine aminotransferase-deficient mice
The deficiency of ornithine aminotransferase (OAT) cause gyrate atrophy, a progressive chorioretinal degeneration disease culminating in blindness. This project investigates age- and tissue-specific proteomic changes in the retina, retinal pigment epithelium (RPE), and liver of OAT-deficient mice to...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-06 | PXD063614 | Pride
Ornithine Metabolism Ornithine aminotransferase Proteomics Gyrate atrophy Retina pigment epithelium Liver Oat Retina 
TranscriptomicsNitrogen-efficient rice over-expressing alanine aminotransferase at three different N concentrations
Oryza sativa cv. Nipponbare was engineered to over-express a barley alanine aminotransferase (alaAT) gene using the promoter (OsANT1) from a rice aldehyde dehydrogenase gene that expresses in roots. We use biotechnology to improve the nitrogen use efficiency of rice by over-expressing alaAT in a tis...
ORGANISM(S): Oryza sativa 
2013-10-25 | GSE48549 | GEO
TranscriptomicsOrnithine aminotransferase supports polyamine synthesis in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) cells have a distinct dependence on de novo ornithine synthesis from glutamine via ornithine aminotransferase (OAT), which supports polyamine synthesis and is required for tumor growth. This directional OAT activity is normally largely restricted to infancy and...
ORGANISM(S): Homo sapiens 
2023-01-01 | GSE193411 | GEO
GenomicsDeep Sequencing Analysis of the MicroRNAs in the Serum of Chronic Hepatitis B with Persistently Normal Alanine Aminotransferase
Background: Circulating miRNAs, a new family of miRNAs presentin plasma and serum, have shown great potential as novel body fluid biomarkers for non-invasive diagnosis and prognosis of several diseases. Methods: In the present study, we employed next-generation sequencing technology to analyze the e...
ORGANISM(S): Homo sapiens 
2016-12-31 | GSE62290 | GEO
TranscriptomicsObese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
It is well established that obese animals and humans show deficiencies in skeletal muscle content and metabolism. However, the mechanisms under how skeletal muscle metabolism affects systemic energy homeostasis is not well-defined. Here, we compared the skeletal muscle transcriptome from obese and l...
ORGANISM(S): Macaca fascicularis 
2023-12-12 | GSE180906 | GEO
TranscriptomicsBranched-chain Amino Acid Aminotransferase-1 Regulates Self-Renewal and Pluripotency of Mouse Embryonic Stem Cells through Ras Signaling
Embryonic stem cells (ESCs) can self-renew indefinitely and have the potential to differentiate into all cell types in the adult organism. Although the developmental plasticity of ESCs is mainly controlled by transcription factors, the intrinsic regulation of this process remains elusive. Here, usin...
ORGANISM(S): Mus musculus 
2019-01-16 | GSE125023 | GEO
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