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GenomicsGenome-wide Runx1 binding sites in early hematopoietic progenitors (FDCP1)
We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse embryonic...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81179 | biostudies-arrayexpress
TranscriptomicsBromodomain protein BRD4 is required for estrogen receptor-dependent transcription and enhancer activation [RNA-Seq]
The estrogen receptor-M-NM-1 (ERM-NM-1) is a transcription factor which plays a critical role in controlling cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to induce or repress gene transcription. A deeper understanding of these transcriptio...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-55922 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Runx1-bound sites in early B-cell progenitors
The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investig...
ORGANISM(S): Mus musculus 
2013-05-27 | E-GEOD-45377 | biostudies-arrayexpress
TranscriptomicsDual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer
Using a retrovirus-mediated cDNA expression cloning approach we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase in cell proliferation, anchorage-independent growth, and t...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43610 | biostudies-arrayexpress
TranscriptomicsGene expression analysis to identify Runx1 target genes in GMP, MEP and Gene expression signature of Runx1Î?/Î? lin- sca- kit+ CD105- CD16/32+ CD150+ (XMP) progenitors
We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse embryonic...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81181 | biostudies-arrayexpress
GenomicsGenome-wide mapping of Mef2c-bound sites in early B-cell progenitors
The sequential activation of distinct developmental gene networks governs the ultimate identity of a cell, but the mechanisms by which downstream programs are activated are incompletely understood. The preB-cell receptor (preBCR) is an important checkpoint of B-cell development and essential for a p...
ORGANISM(S): Mus musculus 
2015-12-14 | E-GEOD-73453 | biostudies-arrayexpress
GenomicsBromodomain protein BRD4 is required for estrogen receptor-dependent transcription and enhancer activation [ChIP-seq]
The estrogen receptor-α (ERα) is a transcription factor which plays a critical role in controlling cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to induce or repress gene transcription. A deeper understanding of these transcriptional mechan...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-55921 | biostudies-arrayexpress
UnknownIntensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial.
Not available
S-EPMC6652154 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
UnknownEvaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Not available
S-EPMC10771257 | biostudies-literature
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