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MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
UnknownDeveloping a patient-oriented realist evaluation for COVID-19 vaccine implementation in Saskatchewan: a methodologic framework.
Not available
S-EPMC8612651 | biostudies-literature
ProteomicsDREX proteome analysis for spectral library
In order to prepare a spectral library for data-indepentend acquisition mass spectrometry studies, we try to cover as many proteins from Drosophila melanogaster embryonic protein extracts.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-02-25 | PXD005100 | Pride
Drosophila embryo proteome Fragmentation pattern Spectral library 
UnknownLipoprotein turnover and possible remnant accumulation in preeclampsia: insights from the Freiburg Preeclampsia H.E.L.P.-apheresis study.
Not available
S-EPMC5853053 | biostudies-literature
ProteomicsA quantitative proteomic analysis of in vitro assembled chromatin
The structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store epigenetic information. It is defined by the histone molecules that constitute the nucleosome, the positioning of the nucleosomes along the DNA and the non-histone prote...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-01-27 | PXD002537 | Pride
Acetylation  affinity proteomics  chromatin function or biology  label-free quantification   macromolecular assemblages 
ProteomicsSimple targeted assays for metabolic pathways and signaling: a powerful tool for targeted proteomics
We introduce STAMPS, a pathway centric web service for the development of targeted proteomics assays. STAMPS guides the user by providing several intuitive interfaces for a rapid and simplified method design. Applying our curated framework to signaling and metabolic pathways, we reduced average assa...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-22 | PXD013343 | Pride
Databases Proteomics Mass spectrometry Proteomic analysis 
ProteomicsPURA Syndrome as a Congenital Myasthenic Disorder: Evidence from Muscle Morphology, Proteomics, and Blood Biomarkers
Dominant PURA variants cause a neurodevelopmental disorder with hypotonia, cognitive impairment, and variable neuromuscular symptoms. Clinical response to pyridostigmine suggests neuromuscular junction (NMJ) involvement, but NMJ architecture, molecular mechanisms, and minimally invasive biomarkers r...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD067750 | Pride
Muscle proteomics Thrombospondin-4 (tsp4) Target of nesh-sh3 (tarsh) Congenital myasthenic syndrome (cms) Extracellular vesicles in neuromuscular diseases Periostin (postn) 
ProteomicsBlood biomarkers in a cohort of patients with CHRNE-associated congenital myasthenic syndrome
Pathogenic variants in CHRNE encoding the epsilon subunit of acetyl choline receptor (AChR) result in impaired neuromuscular transmission and congenital myasthenic syndromes (CMS). Clinical manifestations include facial, ocular and limb fatigability and weakness, whereby severity of symptoms may var...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054347 | Pride
Cms mirna Cms metabolites Cms biomarkers Plec Cms extracellular vesicles Cms white blood cells Cms amino acids 
ProteomicsCombined Histological and Proteomic Analysis Reveals Muscle Denervation in KMT5B-Related Neurodevelopmental Disorder: A Case Report
Background: Patients with neurodevelopmental and neuromuscular disorders often show overlapping clinical phenotypes. Pathogenic variants in KMT5B, a histone lysine methyltransferase, have been linked to neurodevelopmental disorders, yet their effects on human skeletal muscle remain unexplored. We re...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-01-05 | PXD071037 | Pride
Kmt5b  muscle denervation in neurodevelopmental disorders  muscle proteomics  fast-twitch fiber predominance  hypotonia  case report 
MetabolomicsNontargeted and targeted metabolomics measurements of abiotic stress responses in three-week-old Arabidopsis thaliana plants' rosette leaf tissue
Nontargeted and targeted metabolomics measurements of abiotic stress responses in three-week-old Arabidopsis thaliana plants' rosette leaf tissue for Col-0 wild type plants and double/triple knockout mutants of aquaporins (pip2;1 pip2;2 and pip2;1 pip2;2 pip2;4) treated with drought, heat at differe...
2017-07-17 | MTBLS355 | MetaboLights
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