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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
UnknownGenome-wide association study of Fuchs' endothelial corneal dystrophy in the German population.
Not available
S-EPMC12170761 | biostudies-literature
ProteomicsA novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins
Recent developments in affinity binder or mass spectrometry (MS)-based plasma proteomics are now producing panels of potential biomarker candidates for diagnosis or prognosis. However, clinical validation and implementation of these biomarkers remain limited by the reliance on dated triple quadrupol...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-17 | MSV000095051 | MassIVE
ProteomicsOntology-guided clustering enables proteomic analysis of rare pediatric disorders
The study of rare pediatric disorders is fundamentally limited by small patient numbers, making it challenging to draw meaningful conclusions about their molecular basis. To address this, we developed a framework that integrates clinical ontologies with proteomic profiling, enabling the systematic a...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD058960 | Pride
Pediatrics / plasma / proteomics / snomed ct / urine 
ProteomicsA simplified perchloric acid workflow with neutralization (PCA N) for democratizing deep plasma proteomics at population scale - Submission 3
Large scale plasma proteomics studies offer tremendous potential for biomarker discovery but face significant challenges in balancing analytical depth, throughput and cost effectiveness. We present an optimized perchloric acid based workflow with neutralization – PCA N – that addresses these limitat...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD062313 | Pride
Lc-msms Plasma 
ProteomicsAxonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer´s disease (AD). Tau pathology occurs first in axons of affected neurons and tau removal from axons might thus be an early intervention strategy. We report that the RNA-binding protein hnRN...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD053387 | Pride
Antisense oligonucleotide Alzheimer´s disease Amyloid Tau Hnrnp r 
ProteomicsA simplified perchloric acid workflow with neutralization (PCA-N) for democratizing deep plasma proteomics at population scale - Submission04
This project presents PCA-N, a novel plasma proteomics workflow that uses perchloric acid with neutralization to dramatically improve sample preparation efficiency. By eliminating solid-phase extraction and enabling 384-well plate compatibility, PCA-N reduces sample volume requirements to just 5 μL,...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD064487 | Pride
Lc-msms Plasma 
ProteomicsA simplified perchloric acid workflow with neutralization (PCA-N) for democratizing deep plasma proteomics at population scale - Submission 5
This project presents PCAᴺ, a novel plasma proteomics workflow that uses perchloric acid with neutralization to dramatically improve sample preparation efficiency. By eliminating solid-phase extraction and enabling 384-well plate compatibility, PCAᴺ reduces sample volume requirements to just 5 μL, c...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD064475 | Pride
Lc-msms Plasma 
UnknownAnticalin N- or C-Terminal on a Monoclonal Antibody Affects Both Production and In Vitro Functionality.
Not available
S-EPMC9397084 | biostudies-literature
TranscriptomicsKDM6 Inhibition induces DNA Damage Response (DDR) during ESC Differentiation but not during self-renewal.
The discovery of the first histone demethylase in 2004 (LSD1/KDM1) opened new avenues for the understanding of how histone methylation impacts cellular functions. A great number of histone demethylases have been identified since, which are potentially linked to gene regulation as well as to stem cel...
ORGANISM(S): Mus musculus 
2016-03-11 | E-GEOD-49886 | biostudies-arrayexpress
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