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MetabolomicsIntegrated Analyses of the Gut Microbiota, Intestinal Permeability and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome
The etiology of alcohol dependence is not completely understood. Increasing evidence reveals that gut microbiota dysbiosis is associated with certain psychiatric disorders, including alcoholism, through the 'microbiota-gut-brain' axis. The aims were to evaluate the effect of alcohol abuse on the gut...
2021-07-30 | MTBLS2688 | MetaboLights
ProteomicsPresynaptic proteins in the orbitofrontal cortex predict Alcohol Use Disorder
Alcohol use disorder (AUD) is a life-threatening disease characterized by compulsive drinking, cognitive deficits, and social impairment that continue despite negative consequences, which are driven by dysfunction of cortical areas, such as the orbitofrontal cortex (OFC), that normally balances deci...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD041727 | Pride
Machine learning Alcohol drinking Isobaric labeling Alcohol use disorder Sexual dimorphism Mass spectrometry Ap2a1 Orbitofrontal cortex Mitochondria Quantitative proteomics Presynapses Extracellular matrix 
MetabolomicsFasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis

Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable. Harmful use of alcohol is one of the greatest risk factors for de...

2023-05-15 | MTBLS5071 | MetaboLights
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
ProteomicsBrain Proteomic Atlas of Alcohol Use Disorder in Adult Males
Alcohol use disorder (AUD) affects transcriptomic, epigenetic and proteomic expression in several organs including the brain. Multi-omic analyses of the brain from individuals with AUD to date lack a comprehensive analysis of protein alterations in the multiple brain regions that underlie neuroadapt...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040884 | Pride
Alcoholism Brain Proteomics Drug targets Alcohol use disorder 
GenomicsGDF15 in alcohol use disorder
GDF15 in alcohol use disorder Raw sequence reads
PRJNA1366826 | ENA
TranscriptomicsGenes associated with alcohol abuse and nicotine addiction in the human nucleus accumbens
Background: The incidence of alcohol and tobacco co-abuse is as high as 80%. The molecular mechanism underlying this comorbidity is virtually unknown but interactions between these drugs have important implications for the development of, and recovery from drug dependence. Methods: We investigat...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20568 | biostudies-arrayexpress
GenomicsPerturb-seq analysis using genes associated with alcohol consumption and alcohol use disorder
Perturb-seq analysis using genes associated with alcohol consumption and alcohol use disorder
PRJNA1067550 | ENA
GenomicsEpigenetic Moderators of Naltrexone Efficacy for Alcohol Use Disorder
Epigenetic Moderators of Naltrexone Efficacy for Alcohol Use Disorder
PRJNA729135 | ENA
GenomicsEpigenetic Moderators of Naltrexone Efficacy for Alcohol Use Disorder
Epigenetic Moderators of Naltrexone Efficacy for Alcohol Use Disorder
PRJNA729134 | ENA
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