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TranscriptomicsTranscription profiling of mouse inner medullary collecting duct cells treated with aldosterone to characterize early aldosterone-responsive genes.
Murine inner medullary collecting duct cells were treated for 1 hour with vehicle (control) or aldosterone. Total RNA was isolated and used as template to generate the eventual cRNA target. The experiment was repeated a total of three times. Six cRNA samples, three control and three treated, were ge...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-434 | biostudies-arrayexpress
GenomicsCistrome of the Aldosterone-activated Mineralocorticoid Receptor in Human Renal Cells
Aldosterone, the main mineralocorticoid hormone in Humans, has a major role in maintaining the hemo-electrolytique homeostasis, by acting in the distal part of nephron. This steroid hormone mainly acts through its binding to a ligand-induced transcription factor, the mineralocorticoid receptor (MR)....
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-69777 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cortical collecting duct/connecting nephron tissue from mice treated with aldosterone, canrenoate vs. controls to identify gene products regulated by aldosterone in target cells
The mineralocorticoid hormone aldosterone controls sodium reabsorption and blood pressure largely by regulating the cell-surface expression and function of the epithelial sodium channel ENaC in target kidney tubules. Part of the stimulatory effect of aldosterone on ENaC is mediated by the induct...
ORGANISM(S): Mus musculus 
2007-03-07 | E-TABM-229 | biostudies-arrayexpress
TranscriptomicsMicroarray study of human adrenal zona glomerulosa (ZG), zona fasciculata (ZF) and aldosterone-producing adenomas (APA)
Learn about the transcriptome profiling of zona glomerulosa (ZG), zona fasciculata (ZF) and aldosterone-producing adenomas (APA) in human adrenals 21 pairs of zona fasciculata (ZF) and zona glomerulosa (ZG), and 14 paired aldosterone-producing adenomas (APAs) from 14 Conn’s syndrome patients and 7 p...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-64957 | biostudies-arrayexpress
TranscriptomicsAldosterone-Regulated Expression Data in Mouse Aorta
The steroid hormone aldosterone plays a role in vascular function and disease. Aldosterone activates the mineralocorticoid receptor (MR), a ligand-activated transcription factor. MR have been found to be expressed in vascular cells and vessels. We used microarrays to identify the global programme of...
ORGANISM(S): Mus musculus 
2010-08-12 | E-GEOD-23566 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hearts from mice treated with aldosterone for different time duration to study the genetic mechanism of aldosterones direct adverse effects on the heart.
Aldosterone is known to have a number of direct adverse effects on the heart, including fibrosis and myocardial inflammation. However, genetic mechanisms of aldosterone action on the heart remain unclear. This experiment investigated of temporal changes in gene expression profile of the whole heart ...
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-3440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat adrenal zona glomerulosa cells stimulated with aldosterone secretagogues
The mineralocorticoid aldosterone mainly produced by the adrenal gland is essential for life but an abnormal excessive secretion causes severe pathological effects including hypertension and target organ injury in the heart and kidney. The aim of this study was to determine the gene regulatory netwo...
ORGANISM(S): Rattus norvegicus 
2008-10-18 | E-GEOD-8421 | biostudies-arrayexpress
TranscriptomicsTranscriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin
In this study, we analyzed the transcriptome of a highly differentiated mouse clonal CCD principal cell line (mpkCCD(cl4)) and the changes in the transcriptome induced by aldosterone and vasopressin. Serial analysis of gene expression (SAGE) was performed on untreated cells and on cells treated with...
ORGANISM(S): Mus musculus 
2003-09-24 | E-GEOD-678 | biostudies-arrayexpress
TranscriptomicsExpression data from normal adrenal gland and aldosterone-producing adenoma
The source of aldosterone in 30 to 40 % of patients with primary hyperaldosteronism (PA) is unilateral aldosterone-producing adenoma (APA). The mechanisms causing elevated aldosterone production in APA are unknown. Herein, we examined expression of G-protein coupled receptors (GPCR) in APA and demon...
ORGANISM(S): Homo sapiens 
2007-07-18 | E-GEOD-8514 | biostudies-arrayexpress
TranscriptomicsAldosterone regulated genes in distal colon surface cells
Effects of aldosterone on the transcriptome in distal colon. Expression of genes was studied in distal colon surface cells from aldosterone treated vs. vehicle treated rats.
ORGANISM(S): Rattus norvegicus 
2014-09-01 | E-GEOD-50533 | biostudies-arrayexpress
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