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UnknownRandomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed.
Not available
S-EPMC5089161 | biostudies-literature
TranscriptomicsStress-related gene expression in HK-2 cells exposed to pH 7.4, 7.0 or 6.7
Chronic metabolic acidosis occurs commonly in patients with diseased kidneys and is linked with progression to renal failure. As renal function declines there is loss of nephron mass and adaptive proximal tubular hypertrophy and hypermetabolism. We have previously demonstrated in an in vitro model o...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-23995 | biostudies-arrayexpress
ProteomicsMass spectrometry spatial-omics on a single conductive slide
Mass spectrometry imaging (MSI) can analyze the spatial distribution of hundreds of different molecules directly from tis-sue sections usually placed on conductive glass slides to provide conductivity on the sample surface. Additional experiments are often required for molecular identification using...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2021-09-09 | PXD023196 | Pride
Proteomics Conductive slide Maldi-msi Lmd 
MetabolomicsSmall intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an o...
2019-04-30 | MTBLS876 | MetaboLights
TranscriptomicsGenetic heterogeneity versus molecular analysis of prion susceptibility in neuroblasma N2a sublines
The neuroblastoma-derived cell line N2a is permissive to certain prion strains but resistant sublines unable to accumulate the pathological proteinase-K resistant form of the prion protein can be isolated. We compared for gene expression and phenotypes different N2a sublines that were susceptible or...
ORGANISM(S): Mus musculus 
2010-06-19 | E-GEOD-5374 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bone marrow macrophages from IL-6-/- and IL-10-/- mutants treated with IL-10 or IL-6 stimulation in the presence of LPS
IL-10 or IL-6 stimulation of control 129xC57BL/6 murine bone marrow derived macrophages in the presence of LPS. We used microarrays to detail the global programme of gene expression changes in response to IL-6 or IL-10 stimulation in the presence of lipopolysaccharide. BMDMs were isolated from cont...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5589 | biostudies-arrayexpress
ProteomicsCritical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows
Metaproteomics, the study of the collective proteome within a microbial ecosystem, has substantially grown over the past few years. This growth comes from the increased awareness that it can powerfully supplement metagenomics and metatranscriptomics analyses. Although metaproteomics is more challeng...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) Homo Sapiens (ncbitaxon:9606) 
2022-06-08 | MSV000089620 | MassIVE
TranscriptomicsSystems analysis of the response of photosynthesis, metabolism and growth to an increase in irradiance in the photosynthesis model organism Chlamydomonas reinhardtii
Systems analysis reveals that Chlamydomonas reinhardtii responds rapidly and flexibly to an increase in light intensity. Rising metabolite levels and post-translation regulation facilitate a rapid increase in the rate of carbon fixation and a slightly delayed increase in the rate of growth, and slow...
ORGANISM(S): Chlamydomonas reinhardtii 
2014-04-30 | E-GEOD-56800 | biostudies-arrayexpress
TranscriptomicsLoss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition
Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC indu...
ORGANISM(S): Mus musculus 
2015-08-07 | E-GEOD-68808 | biostudies-arrayexpress
UnknownSimvastatin in Critically Ill Patients with Covid-19.
Not available
S-EPMC10755839 | biostudies-literature
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