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ProteomicsHuman NEK10 knockout airway ALI Fe-IMAC-MSMS
We identified inactivating mutations in NEK10, a poorly characterized human protein kinase, in a novel human bronchiectasis syndrome. In order to understand effects of loss of its function on the airway phosphoproteome, NEK10 was CRISPR/Cas9 targeted in human airway air-liquid interface (ALI) cultu...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016600 | Pride
Human Nek10 Phosphoproteomics Airway 
MetabolomicsMetabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson's Disease: A Pilot Study
CSF from unique groups of Parkinson's disease (PD) patients was biochemically profiled to identify previously unreported metabolic pathways linked to PD pathogenesis, and novel biochemical biomarkers of the disease were characterized. Utilizing both 1H NMR and DI-LC-MS/MS we quantitatively profiled ...
2022-09-02 | MTBLS863 | MetaboLights
ProteomicsA method for profiling cell type-specific secretome: the airway microfold cell
Protein secretion is a fundamental mechanism by which cells communicate with one another and shape their environment. Microfold (M) cells are rare, specialized cells in the mucosal epithelium which sample luminal antigens, channel them to the underlying mesenchyme, and regulate the mucosal immune sy...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-18 | PXD068869 | Pride
Proximity ligation Cell polarity  Bira Turboid Microfold cell Secretome Secreted proteome 
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
MetabolomicsEarly postnatal metabolic profile in neonates with different birth weight status: A pilot study

INTRODUCTION: Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this ...

2021-04-28 | MTBLS2376 | MetaboLights
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
UnknownDecoding the amniotic membrane transcriptome during equine ascending placentitis.
Not available
S-EPMC12371064 | biostudies-literature
TranscriptomicsPhenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus
We report the application of RNA sequencing technology for high-throughput profiling of gene expression responses to human rhinovirus infection at 24 hours in air-liquid interface human airway epithelial cell cultures derived from 6 asthmatic and 6 non-asthmatic donors. RNA-seq analysis identified ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-61141 | biostudies-arrayexpress
MetabolomicsA Multi-Omics Analysis of Glycine max Leaves Reveals Alteration in Flavonoid and Isoflavonoid Metabolism Upon Ethylene and Abscisic Acid Treatment
Phytohormones are central to plant growth and development. Despite the advancement in our knowledge of hormone signaling, downstream targets, and their interactions upon hormones action remain largely fragmented, especially at the protein and metabolite levels. With an aim to get new insight into th...
2018-09-20 | MTBLS531 | MetaboLights
UnknownApplication of magnetic deep eutectic solvents as an efficient catalyst in the synthesis of new 1,2,3-triazole-nicotinonitrile hybrids <i>via</i> a cooperative vinylogous anomeric-based oxidation.
Not available
S-EPMC11520567 | biostudies-literature
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