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ProteomicsHuman NEK10 knockout airway ALI Fe-IMAC-MSMS
We identified inactivating mutations in NEK10, a poorly characterized human protein kinase, in a novel human bronchiectasis syndrome. In order to understand effects of loss of its function on the airway phosphoproteome, NEK10 was CRISPR/Cas9 targeted in human airway air-liquid interface (ALI) cultu...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016600 | Pride
Human Nek10 Phosphoproteomics Airway 
ProteomicsA method for profiling cell type-specific secretome: the airway microfold cell
Protein secretion is a fundamental mechanism by which cells communicate with one another and shape their environment. Microfold (M) cells are rare, specialized cells in the mucosal epithelium which sample luminal antigens, channel them to the underlying mesenchyme, and regulate the mucosal immune sy...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-18 | PXD068869 | Pride
Proximity ligation Cell polarity  Bira Turboid Microfold cell Secretome Secreted proteome 
MetabolomicsHigh-Throughput Detection of an Alkaloidal Plant Metabolome in Plant Extracts Using LC-ESI-QTOF-MS.
Plant alkaloids represent a diverse group of nitrogen-containing natural products. These compounds are considered valuable in drug discovery and development. High-throughput identification of such plant secondary metabolites in complex plant extracts is essential for drug discovery, lead optimizatio...
2023-12-12 | MTBLS2914 | MetaboLights
MetabolomicsProteomic and metabolomic profiling of extracellular vesicles produced by human gut archaea

Gastrointestinal bacteria interact with the host and each other through various mechanisms, including the production of extracellular vesicles (EVs). However, the composition and potential roles of EVs released by gut archaea are poorly understood. Here, we study EVs produced by four strains of h...

2025-07-01 | MTBLS12422 | MetaboLights
ProteomicsHuman CCDC114-mutant patient derived air-liquid interface (ALI) organoids proteome
In this experiment we investigate the different expressed proteins between healthy control ALI organoids and CCDC114-mutant ALI organoids.
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD064456 | Pride
Human Organoids Airway Ccdc114 
TranscriptomicsAcute Lung Injury In Experimental Malaria
Although respiratory distress is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria; however, no model of malaria-i...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9497 | biostudies-arrayexpress
UnknownDual Targeting of VEGFR2 and C-Met Kinases via the Design and Synthesis of Substituted 3-(Triazolo-thiadiazin-3-yl)indolin-2-one Derivatives as Angiogenesis Inhibitors.
Not available
S-EPMC7408256 | biostudies-literature
ProteomicsMolecular characterization of Calu-3 cells from submerged to Air-liquid interface to model lung infections
Air-liquid interface (ALI) model using the immortalized Calu-3 cells has been used to model lung diseases. From submerged to ALI culture condition, Calu-3 cells polarize and change to a ciliary mucus-producing cell. Polarized Calu-3 molecular and phenotypic similarity with primary cells has been pro...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD056869 | Pride
Calu-3 Proteomics Ali Polarization 
UnknownLow Genetic Polymorphism in the Immunogenic Sequences of Rhipicephalus microplus Clade C.
Not available
S-EPMC9697226 | biostudies-literature
TranscriptomicsscRNA-seq of canalicular stage human fetal lung cultured under air-liquid interface
Small pieces (<0.5 cm of diameter) were isolated from distal regions of 125 day male human fetal lung and cultured on floating poly-carbonate membranes on top of serum and growth factor free medium under air-liquid interface conditons (ALI). ALI explants underwent changes in gene expression indicati...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-12959 | biostudies-arrayexpress
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