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ProteomicsALKBH7, a mitochondrial member of AlkB family, binds histones in vitro, part 2
Human genome encodes 9 AlkB family members, one of which is ALKBH7. In this study, we found recombinant ALKBH7 could bind bulk histones in GST pull-down and attenuate the signal of H4K20me2 in demethylation assays. With mass spectrometry, we also identified several potential ALKBH7-interacting prote...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD008319 | Pride
Alkbh7 mitochondrion histone 
ProteomicsALKBH7, a mitochondrial member of AlkB family, binds histones in vitro, part 1
Human genome encodes 9 AlkB family members, one of which is ALKBH7. In this study, we found recombinant ALKBH7 could bind bulk histones in GST pull-down and attenuate the signal of H4K20me2 in demethylation assays. With mass spectrometry, we also identified several potential ALKBH7-interacting prote...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD008318 | Pride
Alkbh7 mitochondrion histones 
ProteomicsALKBH7, a mitochondrial member of AlkB family, binds histones in vitro, part 3
Human genome encodes 9 AlkB family members, one of which is ALKBH7. In this study, we found recombinant ALKBH7 could bind bulk histones in GST pull-down and attenuate the signal of H4K20me2 in demethylation assays. With mass spectrometry, we also identified several potential ALKBH7-interacting prote...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD008320 | Pride
Alkbh7 mitochondrion histone 
GenomicsALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
PRJNA623501 | ENA
Methylation profilingALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing
Members of the mammalian AlkB family are known to mediate nucleic acid demethylation. ALKBH7, a mammalian AlkB homologue, localizes in mitochondria (mt) and affects metabolism, but its function and mechanism of action are unknown. Here, we report an approach to site-specifically detect m1A, m3C, m1G...
ORGANISM(S): Homo sapiens 
2021-06-02 | GSE148202 | GEO
UnknownALKBH7 mediates necrosis via rewiring of glyoxal metabolism.
Not available
S-EPMC7442491 | biostudies-literature
UnknownALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
Not available
S-EPMC8716185 | biostudies-literature
UnknownIntegrative pan-cancer analysis reveals the prognostic and immunotherapeutic value of ALKBH7 in HNSC.
Not available
S-EPMC11501379 | biostudies-literature
UnknownThe interactome and proteomic responses of ALKBH7 in cell lines by in-depth proteomics analysis.
Not available
S-EPMC6935500 | biostudies-literature
UnknownALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding.
Not available
S-EPMC5322872 | biostudies-literature
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