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ProteomicsMitotic post-translational modifications of histones promote chromatin compaction in vitro
As histones undergo major changes in their post-translational modifications during mitotic entry, we speculated that the spectrum of cell cycle-specific histone modifications might contribute to chromosome compaction during mitosis. To test this hypothesis, we isolated core histones from interphase ...
ORGANISM(S): Gallus gallus (Chicken) 
2018-10-24 | PXD007116 | Pride
Ptms Chromatin condensation Histones Mitotic histones 
ProteomicsMS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones
Histones and histone variants are essential components of the nuclear chromatin. While mass spectrometry has opened a large window to their characterization and functional studies, their identification from proteomic data remains challenging. Indeed, the current interpretation of mass spectrometry d...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-11 | PXD005489 | Pride
Proteomics Mass spectrometry Histone Chromatin Histone variants 
ProteomicsHistone ADP Ribosylation - Serine is a new target residue for endogenous ADP-ribosylation on histones
ADPr sites on histones obtained from cells were directly identified. We have identified 12 unique ADPr sites in human osteosarcoma cells and report serine ADPr as a new type of histone mark that responds to DNA damage.
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2016-12-22 | PXD005462 | Pride
Adpr Histones Serine Adp ribosylation 
ProteomicsEvidence for the nuclear import of monomeric histones H3.1 & H4
We present here evidence that histones H3.1 and H4 can be imported into the nucleus as monomers in human cells. Using a tether-and-release system to study the cytosolic phase and import dynamics of newly synthesised histones, we find that H3.1 and H4 can be maintained as stable monomers in the cytos...
ORGANISM(S): Homo sapiens (Human) 
2018-09-10 | PXD009915 | Pride
Human Histones 
GenomicsGenome-wide distribution of histones modifications in mouse ESC Rif1+/+ and Rif1-/-
Analyzed histones modifications: H3K9 H3K4 H3K27 H4K20
ORGANISM(S): Mus musculus 
2015-12-24 | E-MTAB-3743 | biostudies-arrayexpress
ProteomicsProteomics analysis of ligated and recombinant human histones H3 and H4
A library of unmodified and differentially modified human histones H3 and H4 was prepared using native chemical ligation as described previously (Bartke et al., 2010; Nakamura et al., 2019). The modification status of histone H3 and H4 products was confirmed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD020773 | Pride
Recombinant histones Ligated histones 
TranscriptomicsMolecular landscape of modified histones in Drosophila heterochromatin
The aim of this study is to analyze the distribution of the modified histones in and around peri-centromeric heterochromatin at high resolutions for understanding the molecular nature of the heterochromatic genes and euchromatin-heterochromatin transition. Since heterochromatin is repeat-rich, strin...
ORGANISM(S): Drosophila melanogaster 
2010-06-29 | E-GEOD-7839 | biostudies-arrayexpress
GenomicsModification of histones and their transcriptional response
Modification of histones and their transcriptional response
PRJNA701057 | ENA
GenomicsHistones ChIP-seq in control and ZNFKD H1 cells
Histones ChIP-seq in control and ZNFKD H1 cells
PRJNA602894 | ENA
ProteomicsOnline Weak Cation Exchange-HILIC × Reversed Phase LC UVPD-HRMS of intact HeLa Histones
Intact HeLa core Histones were analyzed using an online two-dimensional liquid chromatographic separation as well as one dimensional LC (RPLC and WCX-HILIC) coupled with UVPD-MS
ORGANISM(S): Homo sapiens (Human) 
2018-09-19 | PXD008978 | Pride
Histones Top-down proteomics Online 2dlc Uvpd 
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