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ProteomicsUncover New Reactivity of Genetically Encoded Alkyl Bromide Unnatural Amino Acids
Genetically encoded unnatural amino acids (Uaas) with electrophilic moieties are excellent tools to investigate protein-protein interactions (PPIs) both in vitro and in vivo. These Uaas, including a series of alkyl bromide-based Uaas, mainly target cysteine residues to form protein-protein cross-lin...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-04-04 | PXD031159 | Pride
Chemical cross-linking And sumo interactome Unnatural amino acid Protein-protein interactions Genetic code expansion 
ProteomicsCovalent labelling of UNC119 with alkyl bromide compound 7
UNC119 protein was treated with compound 7 (10:1 in excess, overnight) to see if covalent modification can be achieved with this alkyl bromide derivative at E163. Untreated UNC119 was used as negative control in comparison.
ORGANISM(S): Homo sapiens (Human) 
2026-01-08 | PXD067823 | Pride
Targeted covalent inhibitors Unc119 Glu-targeted inhibition Alkyl bromide reactivity 
UnknownUncover New Reactivity of Genetically Encoded Alkyl Bromide Non-Canonical Amino Acids.
Not available
S-EPMC8894327 | biostudies-literature
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S-EPMC5539525 | biostudies-literature
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UnknownSynthesis and reactivity of solid-supported organotrifluoroborates in Suzuki cross-coupling.
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S-EPMC3321116 | biostudies-literature
UnknownNickel-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Alkyl Halides: Mechanism-Informed Design of More General Conditions.
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S-EPMC11831828 | biostudies-literature
UnknownPhotoinduced, Copper-Catalyzed Alkylation of Amines: A Mechanistic Study of the Cross-Coupling of Carbazole with Alkyl Bromides.
Not available
S-EPMC5685493 | biostudies-literature
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