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ProteomicsCovalent labelling of UNC119 with alkyl bromide compound 7
UNC119 protein was treated with compound 7 (10:1 in excess, overnight) to see if covalent modification can be achieved with this alkyl bromide derivative at E163. Untreated UNC119 was used as negative control in comparison.
ORGANISM(S): Homo sapiens (Human) 
2026-01-08 | PXD067823 | Pride
Targeted covalent inhibitors Unc119 Glu-targeted inhibition Alkyl bromide reactivity 
TranscriptomicsDysfunction of Unc119, a transducin-binding protein, leads to cone-rod dystrophy through activating JAK-STAT and NF-kB inflammatory pathways in the mouse retina
Transducin is a heterotrimeric G protein that is a component of the phototransduction cascade in rod and cone photoreceptor cells of the retina. Gnat1, a rod-specific transducin α-subunit, regulates light/dark adaptation by changing its subcellular localization depending on light. Our previous study...
ORGANISM(S): Mus musculus 
2025-12-09 | GSE282222 | GEO
UnknownUNC119 is required for G protein trafficking in sensory neurons.
Not available
S-EPMC3178889 | biostudies-literature
UnknownInteraction and colocalization of CaBP4 and Unc119 (MRG4) in photoreceptors.
Not available
S-EPMC2670247 | biostudies-literature
UnknownLipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119.
Not available
S-EPMC6973269 | biostudies-literature
UnknownC9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration.
Not available
S-EPMC4159571 | biostudies-literature
UnknownInteraction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.
Not available
S-EPMC3190703 | biostudies-literature
UnknownUNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia.
Not available
S-EPMC11735834 | biostudies-literature
GenomicsDysfunction of Unc119, a transducin-binding protein, leads to cone-rod dystrophy through activating JAK-STAT and NF-kB inflammatory pathways in the mouse retina
Dysfunction of Unc119, a transducin-binding protein, leads to cone-rod dystrophy through activating JAK-STAT and NF-kB inflammatory pathways in the mouse retina
PRJNA1187608 | ENA
UnknownSpatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.
Not available
S-EPMC5524651 | biostudies-literature
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