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TranscriptomicsUnexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells
The mesencephalic dopaminergic (mDA) cell system is composed by two major groups of projecting cells in the Substantia Nigra (A9 neurons) and the Ventral Tegmental Area (A10 cells). A9 neurons form the nigrostriatal pathway and are involved in regulating voluntary movements and postural reflexes. Th...
ORGANISM(S): Mus musculus 
2010-02-25 | E-GEOD-16192 | biostudies-arrayexpress
GenomicsATRX-mediated chromatin association of histone variant macroH2A1 regulates alpha globin gene expression
The histone variant macroH2A generally associates with transcriptionally inert chromatin, however the factors that regulate its chromatin incorporation remain elusive. Here, we identify the SWI/SNF helicase, ATRX, as a novel macroH2A interacting protein. Unlike its role in assisting H3.3 chromatin d...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-35339 | biostudies-arrayexpress
TranscriptomicsThe Effects of Globin on Microarray-based Gene Expression Analysis of Mouse Blood
Peripheral whole blood-based gene expression profiling has become one of the most common strategies exploited in the development of clinically relevant biomarkers. However, the ability to identify biologically meaningful conclusions from gene expression patterns in whole blood is highly problematic...
ORGANISM(S): Mus musculus 
2010-07-22 | E-GEOD-19282 | biostudies-arrayexpress
TranscriptomicsComprehensive, high resolution analysis of cis-acting regulatory networks at the alpha globin locus (array)
We have combined the 4C chromosome conformation capture protocol with high throughput, genome-wide sequence analysis to characterise in full a cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10-1000kb), the 4C approach provides a comp...
ORGANISM(S): Homo sapiens 
2013-06-06 | E-GEOD-42383 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of whole blood from sickle-cell disease patients using globin mRNA reduction
Room temperature whole blood mRNA stabilization procedures, such as the PAX gene system, are critical for the application of transcriptional analysis to population-based clinical studies. Global transcriptome analysis of whole blood RNA using microarrays has proven to be challenging due to the high ...
ORGANISM(S): Homo sapiens 
2009-06-20 | E-GEOD-16728 | biostudies-arrayexpress
TranscriptomicsComprehensive, high resolution analysis of cis-acting regulatory networks at the alpha globin locus (HTS)
We have combined the 4C chromosome conformation capture protocol with high throughput, genome-wide sequence analysis to characterise in full a cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10-1000kb), the 4C approach provides a comp...
ORGANISM(S): Homo sapiens 
2013-06-06 | E-GEOD-42382 | biostudies-arrayexpress
TranscriptomicsVariation in RNA-Seq transcriptome profiles of peripheral whole blood from healthy individuals with and without globin depletion
In this study we aimed to assess technical variability associated with globin depletion in addition to assessing general technical variability in RNA-Seq from whole blood derived samples. We compared technical and biological replicates having undergone globin depletion or not and found that globin d...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-53655 | biostudies-arrayexpress
GenomicsLentiviral Vectors for Hematopoietic Stem Cell Gene Therapy Restore α-Globin Expression in α-Thalassemia Red Blood Cells
Lentiviral Vectors for Hematopoietic Stem Cell Gene Therapy Restore α-Globin Expression in α-Thalassemia Red Blood Cells
PRJNA1240240 | ENA
GenomicsRegulation of alpha-like globin gene expression in murine primitive erythropoiesis (ATAC-seq)
Regulation of alpha-like globin gene expression in murine primitive erythropoiesis (ATAC-seq)
PRJNA427277 | ENA
GenomicsRegulation of alpha-like globin gene expression in murine primitive erythropoiesis (NG CaptureC)
Regulation of alpha-like globin gene expression in murine primitive erythropoiesis (NG CaptureC)
PRJNA427276 | ENA
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