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ProteomicsTranscriptome and proteome analysis in LUHMES cells overexpressing alpha-synculein
LUHMES cells share many characteritics with human dopamingeric neurons in the substantia nigra, the cells whose demise is responsible for the motor symptoms in Parkinson’s disease (PD). LUHMES cells can therefore be used bona fide as a model to study pathophysiological processes involved in PD. Prev...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD028322 | Pride
Snca Parkinson’s disease (pd) Luhmes cells Alpha-synculein Neurodegenerative diseases Proteome Transcriptome 
TranscriptomicsSystems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms
Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum and cortex are functionally connected with increasing degrees of alpha-synuclein pathology in Parkinson's disease. Functional and causal pathway analysis o...
ORGANISM(S): Homo sapiens 
2014-09-01 | GSE54282 | GEO
TranscriptomicsSystem-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms
Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum and cortex are functionally connected with increasing degrees of alpha-synuclein pathology in Parkinson's disease. Functional and causal pathway analysis o...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-54282 | biostudies-arrayexpress
ProteomicsSmall molecule inhibitor of NEDD4
WT and A53T alpha-synculein-expressing SH-SY5Y cells were treated with sham (DMSO), NAB2 or NAB17 followed by enrichment with TUBE agarose. Eluents were reduced and alkylated and digested with trypsin using an S-trap. Lyophilized peptides were analyzed by LC-MS/MS followed by label-free quantificati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-17 | MSV000085432 | MassIVE
ProteomicsExpression of human Tau and alpha-synculein in Dictyostelium
Mass Spectrometry and proteomic analysis of D. discoideum strains expressing human tau and alpha-synuclein either alone or in combination.
ORGANISM(S): Dictyostelium Discoideum (ncbitaxon:44689) 
2021-07-19 | MSV000087848 | MassIVE
GenomicsHomo sapiens
Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms
PRJNA236096 | ENA
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