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MetabolomicsGNPS - Untargeted plant metabolomics: Evaluation of lyophilization as sample preparation technique
Data for publication "Untargeted plant metabolomics: Evaluation of lyophilization as sample preparation technique" of Christina Maisl, Maria Doppler, Bernhard Seidl, Christoph Bueschl and Rainer Schuhmacher.
ORGANISM(S): Wheat Cultivar Remus 
2023-04-21 | MSV000091769 | GNPS
ProteomicsIdentification of an allosteric site on the E3 ligase adapter cereblon
Cereblon (CRBN) is the target of thalidomide derivatives that achieve therapeutic efficacy against some hematologic neoplasias by recruiting neosubstrates for degradation. Despite the intense investigation of orthosteric thalidomide derivatives, little is known about alternate binding sites on CRBN....
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD067391 | Pride
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67846 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67845 | biostudies-arrayexpress
UnknownPyruvate kinase splice variants in fibroblasts influence cardiac remodeling after myocardial infarction in male mice.
Not available
S-EPMC12344556 | biostudies-literature
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
ProteomicsIdentification of an allosteric site on the E3 ligase adapter cereblon
Cereblon (CRBN) is the target of thalidomide derivatives that achieve therapeutic efficacy against some hematologic neoplasias by recruiting neosubstrates for degradation. Despite the intense investigation of orthosteric thalidomide derivatives, little is known about alternate binding sites on CRBN....
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD052094 | Pride
UnknownT cells, B cells, and PD-L1 expression in esophageal and gastric adenocarcinoma before and after neoadjuvant chemotherapy: relationship with histopathological response and survival.
Not available
S-EPMC8158033 | biostudies-literature
ProteomicsDesign and evaluation of a cyclobutane diazirine alkyne tag for photoaffinity labeling in cells
Alkyl diazirines are frequently used in photoaffinity labeling to trap and identify small molecule–protein interactions. How-ever, the alkyl diazirine can preferentially label acidic amino acids and acidic protein surfaces in a pH-dependent manner, presumably via a long-lived alkyl diazo intermediat...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD035954 | Pride
Cereblon Diazirine Thalidomide Photoaffinity labeling Binding site mapping 
TranscriptomicsGR and Klf15 regulate gene expression dynamics and integrate signals through feed forward circuitry
The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter metabolism in response to stress. Network properties that allow GR to tune gene expression to match specific physiologic demands are poorly understood. We analyzed the transcriptional consequences of GR activatio...
ORGANISM(S): Mus musculus 
2013-05-13 | E-GEOD-44695 | biostudies-arrayexpress
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