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MetabolomicsAggressive breast cancers secrete heme metabolites to alter macrophage immune suppression and function
The heme catabolism pathway is often elevated in aggressive cancers; however, the impact of this pathway and some of its byproducts on the tumor microenvironment remain largely unknown. In human breast cancers, tumor expression of the heme catabolizing enzyme heme oxygenase-1 (HO-1/HMOX1) is positiv...
2026-04-24 | MTBLS14278 | MetaboLights
TranscriptomicsIL-2Rβ- and CD103-dependent genes in regulatory T cells in the gut mucosa
This study determined the genes that are differentially expressed when regulatory T cells (Tregs) were isolated from the lamina propria of the small and large intestine from mice with impaired IL-2Rβ signaling (designated Y3) or impaired IL-2Rβ signaling and lack of CD103 expression (designated Y3/C...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-56438 | biostudies-arrayexpress
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42424 | biostudies-arrayexpress
UnknownNMDA-receptor antibodies alter cortical microcircuit dynamics.
Not available
S-EPMC6196513 | biostudies-literature
UnknownVirus-Specific CD8+ T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression.
Not available
S-EPMC5360480 | biostudies-literature
UnknownNucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation.
Not available
S-EPMC6820757 | biostudies-literature
UnknownMicroRNA regulation in human CD8+ T cell subsets--cytokine exposure alone drives miR-146a expression.
Not available
S-EPMC4219087 | biostudies-literature
UnknownSuppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2.
Not available
S-EPMC4817941 | biostudies-literature
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44266 | biostudies-arrayexpress
UnknownSynonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements.
Not available
S-EPMC11260358 | biostudies-literature
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