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TranscriptomicsTranscription profiling of mouse macrophages infected with Leishmania amazogensis amastigotes
L. amazonensis (LV79 strain, ref.: MPRO/BR/1972/M1841) amastigotes were added or not to BALB/c mouse bone marrow-derived macrophage cultures at a multiplicity of 4 per macrophage. Parasite-harboring macrophages (samples I1 and I2) and parasite-free ones (samples (UI1 and UI2) were cultured at 34M-0C...
ORGANISM(S): Mus musculus 
2009-01-01 | E-MEXP-1595 | biostudies-arrayexpress
TranscriptomicsDistinct Transcriptional Signatures of Bone Marrow-Derived C57BL/6 and DBA/2 Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes
To determine the modulation of gene expression of C57BL/6 and DBA/2 BMDLs in the presence of living intracellular Leishmania amazonensis amastigotes A genome-wide transcriptional analysis was performed by comparing the gene expression profiles of control DLs and live amastigote-hosting DLs from bot...
ORGANISM(S): Mus musculus 
2013-01-07 | E-GEOD-38261 | biostudies-arrayexpress
ProteomicsThree types of Leishmania mexicana amastigotes: proteome comparison by quantitative proteomic analysis
Leishmania is the unicellular parasite transmitted by phlebotomine sand fly bite. It exists in two different forms; extracellular promastigotes, occurring in the gut of sand flies, and intracellular, round-shaped amastigotes residing mainly in vertebrate macrophages. As amastigotes originating from ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036664 | Pride
Amastigotes L. mexicana 
ProteomicsQuantitative proteomic analysis of amastigotes from Leishmania (L.) amazonensis LV79 and PH8 strains reveals molecular traits associated with the virulence phenotype
Leishmaniasis is an antropozoonosis caused by Leishmania parasites that affects around 12 million people in 98 different countries. The disease has different clinical forms, which depend mainly on the parasite genetics and on the immunologic status of the host. The promastigote form of the parasite ...
ORGANISM(S): Leishmania <subgenus> 
2017-11-16 | PXD006321 | Pride
Clustering Virulence Lesion-derived amastigotes Proteome comparison Leishmania amazonensis 
GenomicsRNA-seq of Leishmania mexicana promastigotes, axenic amastigotes and intracellular amastigotes
RNA-seq of Leishmania mexicana promastigotes, axenic amastigotes and intracellular amastigotes
PRJEB8829 | ENA
TranscriptomicsLeishmania donovani amastigotes: Nelfinavir (NFV)-sensitive (control) vs Nelfinavir-resistant [RNA expression profiling]
Drug resistance is a major public health challenge in Leishmaniasis chemotherapy, particularly in the case of emerging Leishmania/HIV-1 co-infections. Recently, we have delineated the mechanism of cell death induced by the HIV-1 protease inhibitor, Nelfinavir, in the Leishmania parasite. In order to...
ORGANISM(S): Leishmania donovani 
2013-06-27 | E-GEOD-42196 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Leishmania mexicana promastigotes, axenic amastigotes and intracellular amastigotes
We used Illumina sequencing of poly-A selected RNA of Leishmania mexicana (WHO strain MNYC/BZ/62/M379) culture-adapted promastigotes (PRO), axenic amastigotes (AXA) and intracellular amastigotes (AMA) in mouse bone marrow derived macrophages (BMDM), 24h after infection, to map 5' and 3' ends of Leis...
ORGANISM(S): Leishmania mexicana 
2015-09-11 | E-MTAB-3312 | biostudies-arrayexpress
TranscriptomicsLeishmania donovani amastigotes: Nelfinavir (NFV)-sensitive (control) vs Nelfinavir-resistant [Comparative Genomic Hybridization (DNA) profiling]
Drug resistance is a major public health challenge in Leishmaniasis chemotherapy, particularly in the case of emerging Leishmania/HIV-1 co-infections. Recently, we have delineated the mechanism of cell death induced by the HIV-1 protease inhibitor, Nelfinavir, in the Leishmania parasite. In order to...
ORGANISM(S): Leishmania donovani 
2013-06-27 | E-GEOD-42195 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse BALB/c macrophages housing multiplying Leishmania amazonensis amastigotes
In mammals, resident dermal macrophages (MΦs) are subverted by Leishmania (L.) amazonensis amastigotes as host cells permissive for parasite multiplication. These Leishmania are living within a communal parasitophorous vacuole (PV) and are expected to trigger unique MΦ transcriptional signatures. ...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-11497 | biostudies-arrayexpress
TranscriptomicsThe expression profiles of promastigotes and axenic amastigotes in Leishmania donovani
In this study, we examined the transcriptome of Leishmania donovani promastigotes and axenic amastigotes to identify differentially regulated mRNAs utilizing the serial analysis of gene expression Keywords: stage differentiation; axenic amastigotes
ORGANISM(S): Leishmania donovani 
2005-12-20 | GSE3835 | GEO
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