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MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
TranscriptomicsGenomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer.
MicroRNAs are small non-coding RNAs that regulate mRNA function. Recent studies have shown that microRNA expression is altered in tumors. We studied the expression of both microRNAs and mRNAs in 60 primary prostate tumors and 16 non-tumor prostate tissues to evaluate the involvement of microRNAs in ...
ORGANISM(S): Homo sapiens 
2008-08-05 | E-GEOD-8126 | biostudies-arrayexpress
TranscriptomicsIdentification of the receptor tyrosine kinase AXL in triple negative breast cancer as a novel target for the human miR-34a microRNA (gene expression)
Triple negative breast cancer (TNBC) is histologically characterized by the absence of the hormone receptors estrogen and progesterone, in addition to having a negative immunostain for HER-2. The aggressiveness of this disease and lack of targeted therapeutic options for treatment is of high clinic...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21832 | biostudies-arrayexpress
TranscriptomicsAn Immune and Inflammation Signature in Prostate Tumors of Smokers
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-68138 | biostudies-arrayexpress
TranscriptomicsAn Immune and Inflammation Signature in Prostate Tumors of Smokers (part 2)
Current smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor induces metastasis. To identify smoking-induced alterations in human prostate tumors, we analyzed gene and protein expression of tumors from current, past, and never smokers a...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-68136 | biostudies-arrayexpress
TranscriptomicsAn Immune and Inflammation Signature in Prostate Tumors of Smokers (part 3)
Current smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor induces metastasis. To identify smoking-induced alterations in human prostate tumors, we analyzed gene and protein expression of tumors from current, past, and never smokers a...
ORGANISM(S): Mus musculus 
2015-04-22 | E-GEOD-68137 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human normal lung and lung cancer samples to investigate the role of miRNA involvement in lung carcinogenesis
MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate the miRNA involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues.
ORGANISM(S): Homo sapiens 
2005-12-31 | E-TABM-47 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human normal colon and colon cancer samples to investigate the role of miRNA involvement in colon carcinogenesis
MicroRNA (miRNA) expression profiles for colon cancers were examined to investigate the miRNA involvement in colon carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate colon cancers from noncancerous colon tissues.
ORGANISM(S): Homo sapiens 
2005-12-31 | E-TABM-46 | biostudies-arrayexpress
TranscriptomicsAn Immune and Inflammation Signature in Prostate Tumors of Smokers (part 1)
Current smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor induces metastasis. To identify smoking-induced alterations in human prostate tumors, we analyzed gene and protein expression of tumors from current, past, and never smokers a...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-68135 | biostudies-arrayexpress
TranscriptomicsMicroRNA-1 is a candidate tumor suppressor and prognostic marker
MicroRNAs (miRs) are small non-coding RNAs that can function as tumor suppressor genes. We previously reported that miR-1 is among the most consistently down-regulated miRs in primary human prostate tumors. In this follow-up study, we further corroborated this finding in an independent dataset and m...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31620 | biostudies-arrayexpress
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