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TranscriptomicsIdentifying vitamin C and RA-regulated genes in the J1 mESCs
It has been demonstrated that vitamin C enhances reprogramming efficiency during inducing pluripotent stem cells, however, the underlying mechanisms are not fully understood. To find the downstream target genes of vitamin C and investigate the mechanism of vitamin C on reprogramming promotion, we pe...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-43405 | biostudies-arrayexpress
TranscriptomicsC/EBPbeta-2 regulation of gene expression in MCF10A cells
C/EBPbeta-2 results in EMT and ErbB indpendence this project investigated the gene changes in related genes upon C/EBPbeta-2 overexpression in MCF10A cells. We used microarray analysis to detail the global gene expression mediated by C/EBPbeta-2 and identified changes in known EMT genes, however, k...
ORGANISM(S): Homo sapiens 
2010-03-06 | E-GEOD-15065 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Primary cerebellar granule cell precursors (GCPs) cultures were prepared from P7 Bmi-1-/- or wild type to investigate the role of Bmi1 in Shh-mediated shift in gene expression levels
We investigated the role of Bmi1 in Shh-mediated shift in gene expression levels Experiment Overall Design: Primary cerebellar granule cell precursors (GCPs) cultures were prepared from P7 Bmi-1-/- or wild type mice as described before {Messer, 1977 #810}. Cells were grown in Dulbecco MEM high Gluc...
ORGANISM(S): Mus musculus 
2010-02-17 | E-GEOD-19176 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast under conditions of ammonium, L-alanine or L-glutamine limitation
Response of Saccharomyces cerevisiae to Ammonium, L-alanine, or L-glutamine Limitation. The protrotophic laboratory strain CEN.PK113-7D (MAT a) was grown in laboratory fermentors with a working volume of 1 litre at dilution rate (D) of 0.20 per hour (in triplicate for each nitrogen limited condition...
ORGANISM(S): Saccharomyces cerevisiae 
2006-06-13 | E-MEXP-724 | biostudies-arrayexpress
TranscriptomicsGene expression analysis during reprogramming with sequential infecion of Oct4/Klf4/cMyc/Sox2
To further understand the mechanism of reprogramming, the mouse embryonic fibroblast cells were infected with Oct4, Klf4, c-Myc and Sox2 with special sequence. 1) Oct4 and Klf4 containing retrovirus was delivered on day 0. 2) Oct4, Klf4 and c-Myc were delivered on Day 1.5. 3) c-Myc and Sox-2 were de...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-39260 | biostudies-arrayexpress
GenomicsUnbiased Capture Hi-C reveals the potential targets of breast cancer susceptibility loci
Genome-wide association studies have identified over 70 common variants that are associated with breast cancer risk. Most of these variants map to non-protein-coding regions; several map to gene deserts, regions of several hundred kb lacking protein-coding genes. We hypothesized that gene deserts ha...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-55634 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor Givinostat modulates key hematopoietic genes in JAK2V617F cells, affecting proliferation, differentiation and apoptosis
We investigated the mechanism of action of the HDAC inhibitor Givinostat in JAK2V617F cells. We confirm that the drug inhibits colony formation and proliferation and induces apoptosis at doses 2-3 fold lower in JAK2V617F (HEL, UKE1 and SET2) compared to JAK2 wild type cell lines (K562, KU812, THP1 a...
ORGANISM(S): Homo sapiens 
2012-07-16 | E-GEOD-27615 | biostudies-arrayexpress
UnknownGreen flowers need yellow to get noticed in a green world.
Not available
S-EPMC12358037 | biostudies-literature
TranscriptomicsC2C12 Murine Myoblasts over-expressing Eda2r
C2C12 (ATCC, #CRL-1772), a myoblast cell line from the C3H mouse strain, was grown in DMEM (Dulbecco’s Modified Eagle’s Medium, Gibco), supplemented with 10% fetal bovine serum (FBS) (Euroclone, Pero, Italy) and 2 mM L-glutamine (Gibco), and maintained in culture at 37 °C with 5% CO₂, without reachi...
ORGANISM(S): Mus musculus 
2023-09-01 | E-MTAB-13101 | biostudies-arrayexpress
TranscriptomicsmicroArray analysis of miRNA expression of human esophageal cell samples and breast cell samples for comparison with multiplexed ligation-based miRNA detection assay
This experiment was carried out as part of a benchmarking study for Ligo-miR EZ, a ligation based multiplex miRNA detection assay. Differential analysis was performed for miRNA expression among the cell samples tested with the microarray and Ligo-miR EZ assay to confirm that Ligo-miR EZ gave the sam...
ORGANISM(S): Homo sapiens 
2017-04-20 | E-MTAB-5575 | biostudies-arrayexpress
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