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GenomicsAmino acid misincorporation promotes mRNA instability
Amino acid misincorporation promotes mRNA instability
PRJNA766688 | ENA
TranscriptomicsAmino acid misincorporation promotes mRNA instability
Messenger RNA (mRNA) translation can lead to higher rates of mRNA decay, suggesting a role for the ribosome in mRNA destruction. Furthermore, features of an mRNA, such as codon identities, that are directly probed by the ribosome also correlate with mRNA decay rates. Specifically, many amino acids a...
ORGANISM(S): Mus musculus 
2022-03-01 | GSE184874 | GEO
ProteomicsArabidopsis Total Leaf Proteomics Probing Amino Acid Misincorporation
Protein translation is a fundamental principle in cell biology. It requires transfer RNAs (tRNAs) loaded with their cognate amino acid to ensure the accurate incorporation of amino acid into the nascent peptide chain. Bacteria, mitochondria, and plastids synthesize glutaminyl -tRNAs (Gln-tRNAGln) fo...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-06-08 | PXD044972 | Pride
Arabidopsis Amino acid minsincorporation Total leaf protein 
UnknownConditional accumulation of toxic tRNAs to cause amino acid misincorporation.
Not available
S-EPMC6125640 | biostudies-literature
ProteomicsFormation and persistence of polyglutamine aggregates in mistranslating cells
In neurodegenerative diseases, including pathologies with well-known causative alleles, genetic factors that modify severity or age of onset are not entirely understood. We recently documented the unexpected prevalence of transfer RNA (tRNA) mutants in the human population, including variants that c...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027837 | Pride
Trna Amino acid misincorporation Mistranslation 
UnknownConformational dynamics during misincorporation and mismatch extension defined using a DNA polymerase with a fluorescent artificial amino acid.
Not available
S-EPMC8715121 | biostudies-literature
ProteomicsPerserverence of protein homeostasis despite mistranslation of glycine codons with alanine
By physically linking amino acids to their codon assignments, transfer RNAs (tRNAs) are essential for protein synthesis and translation fidelity. Some natural human tRNA variants cause amino acid mis-incorporation at a codon or set of codons. Recent work showed a naturally occurring tRNASer variant ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD034180 | Pride
Trna Amino acid misincorporation Mistranslation 
UnknownEvidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines.
Not available
S-EPMC7595273 | biostudies-literature
UnknownMS-READ: Quantitative measurement of amino acid incorporation.
Not available
S-EPMC5524608 | biostudies-literature
ProteomicsIncorporation of nonproteinogenic amino acids into bacterial proteome analyzed by unbiased quantitative MS of protein modifications
To study incorporation of nonproteinogenic amino acids in bacterial proteome we performed a global, unbiased protein modification analysis of the E. coli K12 strain with defective editing mechanism of the leucyl tRNA synthetase (LeuRS), which in addition to leucine incorporates a nonproteinogenic am...
ORGANISM(S): Escherichia coli 
2016-07-11 | PXD003468 | Pride
Mistranslation Trna synthetase Norvaline Leucine Nonproteinogenic amino acids Orbitrap 
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