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MetabolomicsUsing an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein
INTRODUCTION: The pathogenicity at differing points along the aggregation pathway of many fibril-forming proteins associated with neurodegenerative diseases is unclear. Understanding the effect of different aggregation states of these proteins on cellular processes is essential to enhance understand...
2018-06-11 | MTBLS455 | MetaboLights
TranscriptomicsTranscription profiling of human cholinergic SN56.B5.G4 cells treated with beta-amyloid or hydrogen peroxide
Effect of beta-Amyloid and oxidative stress on gene expression in cholinergic SN56.B5.G4-cells
ORGANISM(S): Mus musculus 
2005-01-01 | E-MEXP-710 | biostudies-arrayexpress
ProteomicsChlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer’s disease
Epidemiological evidence suggests that people chronically exposed to organophosphorus pesticides are at increased risk of neurodegenerative disease. Covalently linked amyloid beta dimers have been isolated from the brains of Alzheimer’s patients. The toxic forms of amyloid beta are amyloid dimers ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-17 | PXD034163 | Pride
Chlorpyrifos oxon Amyloid beta Isopeptide Crosslinks 
TranscriptomicsTranscription profiling of human neuroblastoma cell line SH-SY5Y transfected to produce phenotypes with low, medium or high levels of beta-amyloid peptides with 40 or 42 amino acids
Alzheimer's disease (AD) is characterized by massive neurodegeneration and multiple changes in cellular processes, including neurogenesis. Proteolytic processing of the amyloid precursor protein (APP) plays a central role in AD. Due to varying APP processing, several beta-amyloid peptides are genera...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-MEXP-1913 | biostudies-arrayexpress
ProteomicsImpaired presynaptic proteostasis in the initial stages of amyloid beta proteotoxicity
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimers disease (AD); however, little is known about the early mechanisms that contribute to this accumulation. To objectively assess the impaired protein turnover at early stages of amyloid beta (Abeta) proteotoxic...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-24 | MSV000085004 | MassIVE
ProteomicsNanospectral data of amyloid beta 1-42 and scrambled amyloid beta 1-42
Two carrier-free peptides were synthesized and used in experiments: amyloid beta 42 (DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA), and a scrambled variant with the same chemical constituency as amyloid beta 42 (AIAEGDSHVLKEGAYMEIFDVQGHVFGGKIFRVVDLGSHNVA). To perform blockade current measurements, fir...
ORGANISM(S): Synthesized Peptides 
2022-06-30 | MSV000089779 | MassIVE
TranscriptomicsComparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex
The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse pr...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25926 | biostudies-arrayexpress
ProteomicsThe human amyloid beta peptide interactome
The amyloid beta (Aβ) peptide represents a 37 to 49 amino acids endoproteolytic fragment of the amyloid precursor protein. The cellular biology that governs the formation and clearance of Aβ has been understood to play a critical role in Alzheimer’s disease (AD). The primary objective of this study...
ORGANISM(S): Homo sapiens (Human) 
2017-07-05 | PXD004867 | Pride
Brain Affinity purification Alzheimer’s disease Human Frontal lobe Orbitrap Amyloid beta 
TranscriptomicsTranscription profiling of mouse vehicle and sAPPalpha-treated hippocampal slice cultures
Gene expression changes induced by alpha-secretase cleaved amyloid precursor protein (sAPPalpha) in organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL). Hippocampal slice cultures were treated with phosphate buffered saline (GSM26700, GSM26701, GSM26702) or 1 nM sAPPal...
ORGANISM(S): Mus musculus 
2007-10-10 | E-GEOD-1555 | biostudies-arrayexpress
GenomicsAmyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesity
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesity
PRJNA882101 | ENA
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