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MetabolomicsAnalyzing nicotine action against amyloid toxicity by NMR-pharmacometabolomics: an exploratory study

Alzheimer's disease (AD) is the primary neurodegenerative disease spread worldwide. One of the main histopathological hallmarks of AD is amyloid plaque deposition in the brain. Despite some epidemiological studies demonstrating that cigarette smoke is a factor in predisposing people to AD, nicoti...

2026-06-26 | MTBLS12706 | MetaboLights
ProteomicsAnalysis of Amyloid Plaque Composition in two mouse models of Alzheimer’s disease
MALDI mass spectrometry imaging (MSI) enables label-free, spatially resolved analysis of a wide range of analytes in tissue sections. Quantitative analysis of MSI datasets is typically performed on single pixels or manually assigned regions of interest (ROI). However, many sparse, small objects such...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-15 | PXD020824 | Pride
Alzheimer Maldi Ms imaging Amyloid plaques Linear positive mode Abeta 
ProteomicsComparison of the Amyloid Plaque Proteome in Down Syndrome and Alzheimers Disease
Using unbiased localized proteomics, we analyzed amyloid plaques and adjacent plaque-devoid tissue (non-plaque) from post-mortem paraffin-embedded tissues in three cohorts (n=20/group): Down Syndrome, Early Onset AD, and Late Onset AD. We assessed functional associations using Gene Ontology (GO) enr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-18 | MSV000094800 | MassIVE
TranscriptomicsExpression profiling of laser-microdissected tissue from APPPS1 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15058 | biostudies-arrayexpress
TranscriptomicsExpression profiling of laser-microdissected tissue from Tg2576 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15056 | biostudies-arrayexpress
ProteomicsQuantitative proteomic characterization of senile plaques from Alzheimer's disease and non-demented brain
The deposition of amyloid senile plaques (SPs) play a central role in Alzheimer’s disease (AD), but the mechanisms by which SPs induce neural toxicity are disputed. Genetically engineered mouse models emphasising SPs have had limited success in reproducing the neuropathology of AD, and have also fai...
ORGANISM(S): Homo sapiens (Human) 
2019-02-18 | PXD005824 | Pride
Human Brain Alzheimer's disease Amyloid plaque Senile plaque 
ProteomicsQuantitative proteomic characterization of senile plaques from APP/PS1 mice brain
The deposition of amyloid senile plaques (SPs) plays a central role in Alzheimer’s disease (AD), but the mechanisms by which SPs induce neural toxicity are disputed. Genetically engineered mouse models emphasizing SPs have had limited success in reproducing the neuropathology of AD, and have also fa...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-20 | PXD005876 | Pride
Brain Mouse Alzheimer's disease Amyloid plaque Senile plaque 
ProteomicsImpaired presynaptic proteostasis in the initial stages of amyloid beta proteotoxicity
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimers disease (AD); however, little is known about the early mechanisms that contribute to this accumulation. To objectively assess the impaired protein turnover at early stages of amyloid beta (Abeta) proteotoxic...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-24 | MSV000085004 | MassIVE
ProteomicsProteomic and unbiased post-translational modification profiling of amyloid plaques and surrounding tissue in a transgenic mouse model of Alzheimer’s disease
Amyloid plaques (Aβ plaques) are one of the hallmarks of Alzheimer’s disease (AD). The main constituent of Aβ plaques is beta-amyloid peptides but a complex interplay of other infiltrating proteins also co-localizes. We focused on proteomic differences between Aβ plaques and adjacent control tissue ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-25 | PXD014274 | Pride
Amyloid plaque Alzheimer’s disease Mass spectrometry Post transcriptional modifications Laser capture microdissection 
GenomicsComparative analysis of transcriptome remodeling in plaque associated and plaque distant microglia during amyloid-ß pathology progression
Comparative analysis of transcriptome remodeling in plaque associated and plaque distant microglia during amyloid-ß pathology progression
PRJNA843381 | ENA
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