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TranscriptomicsComparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex
The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse pr...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25926 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse vehicle and sAPPalpha-treated hippocampal slice cultures
Gene expression changes induced by alpha-secretase cleaved amyloid precursor protein (sAPPalpha) in organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL). Hippocampal slice cultures were treated with phosphate buffered saline (GSM26700, GSM26701, GSM26702) or 1 nM sAPPal...
ORGANISM(S): Mus musculus 
2007-10-10 | E-GEOD-1555 | biostudies-arrayexpress
ProteomicsIntegrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
Aβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer’s disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recovered the Drosophila ortholog of APP, Appl, in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-10-04 | PXD041862 | Pride
Proteomics Ubiquitinomics Amyloid precursor protein like Appl Drosophila melanogaster 
TranscriptomicsDelayed cell cycling in DS Ts1Cje neural precursor cells results in gene expression dysregulation
Down syndrome neurophenotypes are characterized by mental retardation and a decreased brain volume. In order to identify whether deficits in proliferation, differentiation or survival could be responsible for this phenotype, neural precursor cells (NPCs) were isolated from the developing E14 neocort...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-9805 | biostudies-arrayexpress
UnknownAmyloid precursor protein and amyloid precursor-like protein 2 in cancer.
Not available
S-EPMC4991393 | biostudies-literature
TranscriptomicsTranscriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.
Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls. Mouse hippocampus were dissected for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48622 | biostudies-arrayexpress
UnknownData on thrombotic ischemic lesions in the presence or absence of amyloid ß-protein precursor or its homolog amyloid precursor-like protein-2 in mice.
Not available
S-EPMC4706567 | biostudies-literature
UnknownAmyloid precursor like protein-1 promotes JNK-mediated cell migration in Drosophila.
Not available
S-EPMC5564802 | biostudies-literature
TranscriptomicsThe Nrd1-like protein Seb1 coordinates co-transcriptional 3’ end processing and polyadenylation site selection
Termination of RNAPII transcription is associated with RNA 3’ end formation. For coding genes, termination is initiated by the cleavage/polyadenylation machinery. In contrast, a majority of noncoding transcription events in S. cerevisiae do not rely on RNA cleavage for termination, but instead ter...
ORGANISM(S): Schizosaccharomyces pombe 
2016-07-22 | E-GEOD-82326 | biostudies-arrayexpress
UnknownAn NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.
Not available
S-EPMC4489158 | biostudies-literature
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