Sort   by:  
 Page size 
MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
ProteomicsPhenylalanine Impairs Insulin Signaling and Inhibits Glucose Uptake Through Modification of IRβ
Whether amino acids act on cellular insulin signaling remains unclear, given that increased circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here, we report that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose upta...
ORGANISM(S): Homo sapiens (Human) 
2022-07-22 | PXD035076 | Pride
Type 2 diabetes Phenylalanylation Insulin receptor 
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
UnknownStructural basis for Gemin5 decamer-mediated mRNA binding.
Not available
S-EPMC9440017 | biostudies-literature
MetabolomicsOmics analysis in truffle (Tuber magnatum Pico): comparison of samples from different regions of Italy and from different seasons
Truffles are among the most expensive foods available in the market, usually used as flavoring additives for their distinctive aroma. The most valuable species is Tuber magnatum Pico, better known as 'Alba white truffle', in which bis(methylthio)methane is the key aroma compound. Given the high econ...
2020-12-10 | MTBLS808 | MetaboLights
ProteomicsQuantitative proteomics of candidate biomarkers in NSCLC-derived extracellular vesicles using parallel reaction monitoring assay
Quantitative proteomics of candidate biomarkers in NSCLC-derived extracellular vesicles using parallel reaction monitoring assay
ORGANISM(S): Homo Sapiens 
2024-08-07 | PXD054691 |
MetabolomicsFlavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves
Ginkgo leaves are always resources for flavonoids pharmaceutical industry. However, the effect of the elevation and tree age changes on flavonoid biosynthesis have not been detailly explored in Ginkgo leaves. In addition, whether these environmental pressures have similar effects on the biosynthesis...
2020-12-14 | MTBLS962 | MetaboLights
ProteomicsHuman neuronal extracellular vesicles contain a transcriptional network and tetraspanin-defined subpopulations
Healthy brain function is mediated by several complementary signalling pathways, many of which are driven by extracellular vesicles (EVs). EVs are heterogeneous in both size and cargo and are constitutively released from cells into the extracellular milieu. They are subsequently trafficked to recipi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015255 | Pride
Human Neuron Ipsc Lc-ms/ms 
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
TranscriptomicsDetecting novel low-abundant transcripts in Drosophila
Increasing evidence suggests that low-abundant transcripts may play fundamental roles in biological processes. In an attempt to estimate the prevalence of low-abundant transcripts in eukaryotic genomes, we performed a transcriptome analysis in Drosophila using the SAGE technique. We collected 244,31...
ORGANISM(S): Drosophila melanogaster 
2005-06-03 | E-GEOD-2347 | biostudies-arrayexpress
Sort   by:  
 Page size