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ProteomicsMetabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in 2 nonalcoholic steatohepatitis
In this study Guo et al. revealed an endocrine pathway regulated by skeletal muscle IRF4 that manipulates liver pathology. Mice with skeletal muscle specific ablation of IRF4 show ameliorated liver steatosis, inflammation, and fibrosis, without changes in body weight on nonalcoholic steatohepatitis ...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-13 | PXD045324 | Pride
Mouse serum lcms 
ProteomicsChemoproteomic Profiling of Reactive Cysteines in Response to Oxidative Stress Induced by 6-Hydroxydopamine
Oxidative stress is a well-known driver of neurodegeneration, yet it remains poorly understood how the global cysteine (Cys) proteome is remodeled in such conditions. Proteins with aberrantly modified Cys in response to oxidative stress can induce and exacerbate neurodegeneration. In this study, we ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD060980 | Pride
Quantitative proteomics Cell stress response Sh-sy5y Oxidative stress Neurodegeneration Neurodegenerative signaling 6-hydroxydopamine Cysteine proteomics 
ProteomicsRNF114 Co-IP experiments to identify binding partners
To identify the substrates of RNF114 in the context of PARylation-mediated DDR, we performed an IP-MS (immunoprecipitation coupled with MS) experiment, using cells treated with either H2O2 or H2O2+Talazoparib. We identified a large number of PARP1 peptides from the RNF114 immunoprecipitants only in ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045231 | Pride
Rnf114 chromatin parp1 
ProteomicsQuantitative Phosphoproteomic Analyses Identify STK11IP as a Lysosome-Specific Substrate of mTORC1 that Regulates Lysosomal Acidification
The evolutionarily conserved serine/threonine kinase mTORC1 is a central regulator of cell growth and proliferation. mTORC1 is activated on the lysosome surface. However, once mTORC1 is activated, it is unclear whether mTORC1 phosphorylates local lysosomal proteins to regulate specific aspects of ly...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031543 | Pride
Phosphoproteomics stk11ip 
ProteomicsQuantitative Proteomic Analysis Identifies IGFBP5 as a Secreted Marker for ASCL1High Pulmonary Neuroendocrine Tumors
Lung cancer is the leading cause of cancer death in the United States. Among the various subtypes of lung cancers, pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC) and NE-non-small cell lung cancer (NE-NSCLC), is a particularly aggressive malignancy that is distinct from...
ORGANISM(S): Homo sapiens (Human) 
2019-07-03 | PXD013298 | Pride
Neuroendocrine lung cancer Ascl1 Proteomics and mass spectrometry Secretome Small cell lung cancer 
ProteomicsQuantitative Proteomic Analysis Identifies IGFBP5 as a Secreted Marker for ASCL1High Pulmonary Neuroendocrine Tumors
Lung cancer is the leading cause of cancer death in the United States. Among the various subtypes of lung cancers, pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC) and NE-non-small cell lung cancer (NE-NSCLC), is a particularly aggressive malignancy that is distinct from...
ORGANISM(S): Homo sapiens (Human) 
2019-07-22 | PXD013267 | Pride
Neuroendocrine lung cancer Ascl1 Proteomics and mass spectrometry Secretome Small cell lung cancer 
ProteomicsA chromatin re-localization screen for the identification of Poly-ADP-ribosylation (PARylation)-dependent DNA repair factors.
A chromatin re-localization screen for the identification of Poly-ADP-ribosylation (PARylation)-dependent DNA repair factors.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045229 | Pride
Chromatin relocalization parylation screen 
ProteomicsUncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014840 | Pride
Rucaparib Parylated proteome Hela cell Irucaparib-tp3 Irucaparib 
ProteomicsInduced Degradation of Lineage-specific Oncoproteins Underlies the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer
A subset of small cell lung cancer (SCLC) shows a clinical response to PARP inhibitors (PARPi) despite being proficient in homologous repair pathways. However, the underlying mechanism(s) of PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified proteomic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD029972 | Pride
Quantitative proteomics Ascl1 Lineage-specific oncoproteins Synergistic effect Pips Parp1 inhibitor Predictive biomarkers A histone demethylase Brca1/2 Small cell lung cancer Homologous recombination 
ProteomicsInduced Degradation of Lineage-specific Oncoproteins Underlies the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer (batch2-6)
A subset of small cell lung cancer (SCLC) shows a clinical response to PARP inhibitors (PARPi) despite being proficient in homologous repair pathways. However, the underlying mechanism(s) of PARPi sensitivity is poorly understood. We performed quantitative proteomic analyses and identified proteomic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD029968 | Pride
Quantitative proteomics Ascl1 Lineage-specific oncoproteins Synergistic effect Pips Parp1 inhibitor Predictive biomarkers A histone demethylase Brca1/2 Small cell lung cancer Homologous recombination 
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