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ProteomicsEnhanced STEAP4 Ubiquitination in Obesity: Insights from Combined Proteome and Ubiquitylome Analysis of Visceral Adipose Tissue
Obesity remains a worldwide health issue, with visceral adipose tissue as a leading driver of this pathology. As the executors of biological functions in living cells, proteins have their activity regulated by diverse post-translational modifications, including ubiquitination. However, obesity-relat...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-26 | PXD070339 | Pride
ProteomicsEnhanced STEAP4 ubiquitination in Obesity: Insights from Integrated Proteome and Ubiquitylome Analysis of Visceral Adipose Tissue
We obtained the global proteomic and ubiquitylomic data of epididymal VAT from lean and obese male mice by mass spectrometry. Our proteomic analyses revealed significant changes of metabolic pathways involved in fatty acid, acyl-CoA and branched chain amino acids metabolism in obese VAT. Intriguingl...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-23 | PXD060435 | Pride
Ubiquitylome Obesity Steap4 Proteome 
UnknownRegulatory mechanisms and therapeutic potential of JAB1 in neurological development and disorders.
Not available
S-EPMC10291812 | biostudies-literature
MetabolomicsUntargeted Metabolomics of the enthesis interstitial fluid of wild-type and Nlrp3-/- mice with sham operation and injury post 7 days
In order to investigate the effect of the NLRP3 inflammasome on the regeneration of enthesis, we established an enthesis injury and repair model in wild-type and NLRP3-/- mice. The interstitial fluid of enthesis was extracted, and untargeted metabolomics was conducted to discover differential metabo...
2025-07-08 | MTBLS12150 | MetaboLights
ProteomicsA blood-based multi-omic landscape for the molecular characterization of Kidney Stone Disease
We adopted high-throughput sequencing and mass spectrometry (MS) techniques in this study and carried out an integrative analysis of exosome proteome and DNA methylation data from blood samples of normal and Kidney stone disease patients to screen biomarkers.
ORGANISM(S): Homo Sapiens 
2023-08-10 | PXD044503 |
ProteomicsPTMC_The proteomic profiles of pyridinium-based strategy for lysine-selective protein modification in live cells
A new bioorthogonal lysine-labeling strategy based on cationic-pyridinium activated ester, which renders the modification of peptides and proteins’ lysine residues with ultrafast kinetics and excellent specificity under aqueous solution, and profiled reactive-lysine proteome in vitro and in live cel...
ORGANISM(S): Homo Sapiens 
2023-10-24 | PXD036388 |
ProteomicsTunable activated esters for lysine labeling in proteome
The development of various heteroaromatic activated esters designed for selective lysine labeling within the proteome for profiling purposes. Through systematic optimization of the reactivity and selectivity of these esters, we identified a series of effective probe molecules suitable for both in vi...
ORGANISM(S): Homo Sapiens 
2024-04-09 | PXD051323 |
ProteomicsIntegrative analysis of multi-omic data for the characteristics of the Endometrial Cancer
We constructed a prognostic-gene-based model for EC prediction and found exosomes participate in EC incidents, providing more support for the diagnosis of EC.
ORGANISM(S): Homo Sapiens 
2023-09-08 | PXD045217 |
ProteomicsPTMC_A pyridinium-based strategy for bioorthogonal conjugation-assisted purification method for profiling cell surface proteome
Cell surface proteins (CSPs) are valuable targets for therapeutic agents, but achieving highly selective CSP enrichment in cellular physiology remains a technical challenge. To address this challenge, we propose a newly developed sulfo-pyridinium-ester (SPE) cross-linking probe, followed by two-step...
ORGANISM(S): Homo Sapiens 
2023-08-11 | PXD044541 |
UnknownGut microbiota modulates depressive-like behaviors induced by chronic ethanol exposure through short-chain fatty acids.
Not available
S-EPMC11539449 | biostudies-literature
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