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MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
ProteomicsIdentification of cellular CDK9 substrates using an analog-sensitive cell line
Analog-sensitive kinase technology allows for specific inhibition of a given kinase. Here we utilize an analog-sensitive CDK9 cell line to determine the impact of CDK9 inhibition on the phospho-proteome of human cells. Specifically, we aim to identify substrates of CDK9 in a quantitative way using s...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD014825 | Pride
Analog-sensitive Mass spectrometry P-tefb Protein phosphorylation 
TranscriptomicsTranscription profiling of human activated T lymphocytes to determine the effects of TX527, a hypocalcemic vitamin D analog
Hypocalcemic vitamin D analogs are appealing molecules to exploit the immunomodulatory actions of active vitamin D in vivo. The functional modulation of dendritic cells is regarded as the key mechanism underlying their ability to regulate T cell responses. In contrast, the direct actions of vitamin ...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-23984 | biostudies-arrayexpress
ProteomicsIdentification of RSK substrates using an analog-sensitive kinase approach
RSK1 and RSK4 are two of the four members of the p90 ribosomal protein S6 kinases (RSK) family. These kinases are downstream kinases of mitogen-activated protein kinase 1 (ERK or MAPK1) in the ERK MAP kinase pathway. RSKs are implicated in fine tuning of cellular processes such as translation, trans...
ORGANISM(S): Homo sapiens (Human) 
2024-02-06 | PXD047020 | Pride
Rsk1 Rsk4 Mapk pathway Kinase Substrate 
GenomicsMajusculamide-o, a Simplified Marine Natural Product Analog, Exhibits Potent and Specific Cancer Cell Cytotoxicity
Majusculamide-o, a Simplified Marine Natural Product Analog, Exhibits Potent and Specific Cancer Cell Cytotoxicity
PRJNA1304560 | ENA
GenomicsNAD+ Analog-sensitive PARPs Reveal a Role for PARP-1 in Transcription Elongation
NAD+ Analog-sensitive PARPs Reveal a Role for PARP-1 in Transcription Elongation
PRJNA299154 | ENA
ProteomicsThe innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for post-translational modifications by host and pathogen
TGF-β Activated Kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK fa...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD004213 | Pride
Kinase Covalent capture Kinase substrates Analog specific kinase 
UnknownAn Affinity-Based, Cysteine-Specific ATP Analog for Kinase-Catalyzed Crosslinking.
Not available
S-EPMC8084585 | biostudies-literature
UnknownThe RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition.
Not available
S-EPMC2504292 | biostudies-literature
UnknownGeneration and characterization of ATP analog-specific protein kinase Cδ.
Not available
S-EPMC4303651 | biostudies-literature
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