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GenomicsDepletion or cleavage of cohesin during anaphase differentially affects chromatin structure and segregation
Depletion or cleavage of cohesin during anaphase differentially affects chromatin structure and segregation
PRJNA760947 | ENA
TranscriptomicsDisplacement and re-accumulation of centromeric cohesin during transient pre-anaphase centromere splitting
The ring-shaped cohesin complex links sister chromatids until their timely segregation during mitosis. Cohesin is enriched at centromeres, where it provides the cohesive counter-force to bi-polar tension produced by the mitotic spindle. As a consequence of spindle tension, centromeric sequences tran...
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-29 | E-GEOD-8661 | biostudies-arrayexpress
GenomicsAnaphase-promoting complex-dependent control of cell identity
Anaphase-promoting complex-dependent control of cell identity
PRJNA504508 | ENA
ProteomicsSUMO targets the APC/C in a phosphorylation-dependent manner to regulate transition from metaphase to anaphase
Signal transduction by Small Ubiquitin-like Modifier (SUMO) regulates a myriad of nuclear processes. Here, we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery resulted in a delay in mitosis and defects in mitotic chromosome separation. Searching...
ORGANISM(S): Homo sapiens (Human) 
2018-09-19 | PXD006335 | Pride
Anaphase promoting complex Apc4 Sumo Mitosis Phosphorylation Chromatin bridges Kif18b Ubiquitin 
ProteomicsSUMOylation regulates the metaphase-anaphase transition by stabilizing sister kinetochore biorientation
The accurate segregation of chromosomes during mitosis relies on the attachment of sister chromatids to microtubules from opposite poles, called biorientation. Sister chromatid cohesion resists microtubule forces, generating tension which provides the signal that biorientation has occurred. How tens...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-05-06 | PXD015565 | Pride
Yeast sumo smt3 sgo1 
GenomicsCondensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase
Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase
PRJNA803474 | ENA
GenomicsDepletion or cleavage of cohesin during anaphase differentially affects chromatin structure and segregation
Chromosome segregation requires both the separation of sister chromatids and the sustained condensation of chromatids during anaphase. In yeast cells, cohesin is not only required for sister chromatid cohesion but also plays a major role in determining the structure of individual chromatids in metap...
ORGANISM(S): Saccharomyces cerevisiae 
2022-10-01 | GSE183481 | GEO
GenomicsSmc3 deacetylation by Hos1 facilitates efficient dissolution of sister chromatid cohesion during anaphase
Sister chromatid cohesion relies on cohesins, a group of proteins that forms a ring-shaped complex embracing sister chromatids. Cohesion is established during S phase and is removed when cohesin Scc1 is cleaved by the protease separase at anaphase onset. During this process, the cohesin subunit Smc3...
ORGANISM(S): Saccharomyces cerevisiae 
2017-11-02 | GSE96841 | GEO
UnknownA Wee1 checkpoint inhibits anaphase onset.
Not available
S-EPMC3678162 | biostudies-literature
UnknownThe anaphase-promoting complex/cyclosome is required for anaphase progression in multinucleated Ashbya gossypii cells.
Not available
S-EPMC1797942 | biostudies-literature
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