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MetabolomicsCoupling Inflammatory Resolution to Osteogenesis: Lymphatic Vessels as Stage-specific Niche Regulators in Skeletal Healing

Skeletal healing requires the coordinated resolution of inflammation and precise lineage commitment of mesenchymal progenitors, yet the mechanisms coupling these processes remain incompletely defined. Here, we reveal that lymphatic vessels in bone serve as dynamic orchestrato...

2026-01-17 | MTBLS13645 | MetaboLights
MetabolomicsLimosilactobacillus reuteri with indole-3-lactic acid-producing capacity protects against atherosclerosis by fortifying the gut-vascular barrier

Introduction: The gut microbiota and its metabolites are implicated in atherosclerosis, but the specific effector molecules and their pathophysiological significance remain unclear.

Objectives: This study aimed to identify key atheroprotective microbial metabolites and to elucidate the mech...

2026-01-31 | MTBLS13620 | MetaboLights
ProteomicsTemporal multi-omics identifies LRG1 as vascular instructor of early metastatic colonization.
Metastasis is the primary cause of cancer-related mortality and the mechanistically least well understood step of the tumor progression cascade. Employing surgical preclinical metastasis models, we show here that small primary tumors reprogram the body’s vascular endothelium to alter systemic homeos...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-16 | PXD013978 | Pride
And vascular niche Lrg1 Endothelial cells Cancer Metastasis 
TranscriptomicsReprogramming of Endothelium Into Hematopoietic Progenitors by Defined Factors and Vascular Induction
Generation of abundant engraftable hematopoietic cells from autologous tissues promises new therapies for hematologic diseases. Differentiation of pluripotent stem cells into hematopoietic cells results in emergence of cells that have poor engraftment potential. To circumvent this hurdle, we have d...
ORGANISM(S): Homo sapiens 
2014-07-11 | E-GEOD-57662 | biostudies-arrayexpress
TranscriptomicsIsolation and functional characterization of the arteriole hematopoietic stem cell niche
Hematopoietic stem cells (HSCs) inhabit distinct microenvironments within the adult bone marrow (BM) that govern the delicate balance between HSC quiescence, self-renewal, and differentiation. It has been suggested that quiescent HSCs localize adjacent to BM arteriole endothelial cells in a signific...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-61636 | biostudies-arrayexpress
Genomics3D brain vascular niche model captures invasive behavior and gene signatures of glioblastoma
3D brain vascular niche model captures invasive behavior and gene signatures of glioblastoma
PRJNA1126723 | ENA
UnknownEditor's Choice - Real World Study of Mortality After the Use of Paclitaxel Coated Devices in Peripheral Vascular Intervention.
Not available
S-EPMC9839562 | biostudies-literature
TranscriptomicsThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Gene expression analysis of purified KitL-tomato+ and KitL-tomato- thymic vascular endothelial cells, cortical and medullary thymic epithelial cells from 5 weeks old male kitL-tomato reporter mice Differentially expressed genes analysis of thymic stromal cells
ORGANISM(S): Mus musculus 
2016-01-18 | E-GEOD-62741 | biostudies-arrayexpress
GenomicsCardiovascular disease perturbs the vascular hematopoietic stem cell niche
Cardiovascular disease perturbs the vascular hematopoietic stem cell niche
PRJNA603792 | ENA
GenomicsSteatohepatitis-induced vascular niche alterations promote melanoma metastasis II
Steatohepatitis-induced vascular niche alterations promote melanoma metastasis II
PRJNA1101552 | ENA
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